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Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions.
Kraakman-van der Zwet M, Overkamp WJ, van Lange RE, Essers J, van Duijn-Goedhart A, Wiggers I, Swaminathan S, van Buul PP, Errami A, Tan RT, Jaspers NG, Sharan SK, Kanaar R, Zdzienicka MZ. Kraakman-van der Zwet M, et al. Among authors: sharan sk. Mol Cell Biol. 2002 Jan;22(2):669-79. doi: 10.1128/MCB.22.2.669-679.2002. Mol Cell Biol. 2002. PMID: 11756561 Free PMC article.
BRCA2 deficiency in mice leads to meiotic impairment and infertility.
Sharan SK, Pyle A, Coppola V, Babus J, Swaminathan S, Benedict J, Swing D, Martin BK, Tessarollo L, Evans JP, Flaws JA, Handel MA. Sharan SK, et al. Development. 2004 Jan;131(1):131-42. doi: 10.1242/dev.00888. Epub 2003 Dec 3. Development. 2004. PMID: 14660434
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.
Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F, Yang YP, Petukhova GV, Eckhaus M, Feigenbaum L, Manova K, Kruhlak M, Camerini-Otero RD, Sharan S, Nussenzweig M, Nussenzweig A. Difilippantonio S, et al. Nat Cell Biol. 2005 Jul;7(7):675-85. doi: 10.1038/ncb1270. Epub 2005 Jun 19. Nat Cell Biol. 2005. PMID: 15965469
88 results