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Shared decision-making following disclosure of coronary heart disease genetic risk: results from a randomized clinical trial.
Jouni H, Haddad RA, Marroush TS, Brown SA, Kruisselbrink TM, Austin EE, Shameer K, Behnken EM, Chaudhry R, Montori VM, Kullo IJ. Jouni H, et al. J Investig Med. 2017 Mar;65(3):681-688. doi: 10.1136/jim-2016-000318. Epub 2016 Dec 19. J Investig Med. 2017. PMID: 27993947 Free PMC article. Clinical Trial.
Whether disclosure of genetic risk for coronary heart disease (CHD) influences shared decision-making (SDM) regarding use of statins to reduce CHD risk is unknown. We randomized 207 patients, age 45-65 years, a …
Whether disclosure of genetic risk for coronary heart disease (CHD) influences shared de …
Design of a randomized controlled trial of disclosing genomic risk of coronary heart disease: the Myocardial Infarction Genes (MI-GENES) study.
Kullo IJ, Jouni H, Olson JE, Montori VM, Bailey KR. Kullo IJ, et al. BMC Med Genomics. 2015 Aug 15;8:51. doi: 10.1186/s12920-015-0122-0. BMC Med Genomics. 2015. PMID: 26271327 Free PMC article. Clinical Trial.
We describe design of the Myocardial Infarction Genes (MI-GENES) Study, a randomized clinical trial to assess whether disclosing a GRS for coronary heart disease (CHD) leads to lowering of low-density lipoprotein cholesterol (LDL-C) level …
We describe design of the Myocardial Infarction Genes (MI-GENES) Study, a randomized clinical trial to assess whether d …
Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates: Effect on Low-Density Lipoprotein Cholesterol Levels (the MI-GENES Clinical Trial).
Kullo IJ, Jouni H, Austin EE, Brown SA, Kruisselbrink TM, Isseh IN, Haddad RA, Marroush TS, Shameer K, Olson JE, Broeckel U, Green RC, Schaid DJ, Montori VM, Bailey KR. Kullo IJ, et al. Circulation. 2016 Mar 22;133(12):1181-8. doi: 10.1161/CIRCULATIONAHA.115.020109. Epub 2016 Feb 25. Circulation. 2016. PMID: 26915630 Free PMC article. Clinical Trial.
BACKGROUND: Whether knowledge of genetic risk for coronary heart disease (CHD) affects health-related outcomes is unknown. ...Participants in the (+)GRS group were stratified as having high or average/low GRS. Risk was disclosed by a g …
BACKGROUND: Whether knowledge of genetic risk for coronary heart disease (CHD) affects health-related out …