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Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin.
Sáez-Calvo G, Sharma A, Balaguer FA, Barasoain I, Rodríguez-Salarichs J, Olieric N, Muñoz-Hernández H, Berbís MÁ, Wendeborn S, Peñalva MA, Matesanz R, Canales Á, Prota AE, Jímenez-Barbero J, Andreu JM, Lamberth C, Steinmetz MO, Díaz JF. Sáez-Calvo G, et al. Among authors: sharma a. Cell Chem Biol. 2017 Jun 22;24(6):737-750.e6. doi: 10.1016/j.chembiol.2017.05.016. Epub 2017 Jun 1. Cell Chem Biol. 2017. PMID: 28579361 Free article.
CLASP Suppresses Microtubule Catastrophes through a Single TOG Domain.
Aher A, Kok M, Sharma A, Rai A, Olieric N, Rodriguez-Garcia R, Katrukha EA, Weinert T, Olieric V, Kapitein LC, Steinmetz MO, Dogterom M, Akhmanova A. Aher A, et al. Among authors: sharma a. Dev Cell. 2018 Jul 2;46(1):40-58.e8. doi: 10.1016/j.devcel.2018.05.032. Epub 2018 Jun 21. Dev Cell. 2018. PMID: 29937387 Free PMC article.
Centriole length control.
Sharma A, Olieric N, Steinmetz MO. Sharma A, et al. Curr Opin Struct Biol. 2021 Feb;66:89-95. doi: 10.1016/j.sbi.2020.10.011. Epub 2020 Nov 18. Curr Opin Struct Biol. 2021. PMID: 33220554 Free article. Review.
Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth.
Sharma A, Aher A, Dynes NJ, Frey D, Katrukha EA, Jaussi R, Grigoriev I, Croisier M, Kammerer RA, Akhmanova A, Gönczy P, Steinmetz MO. Sharma A, et al. Dev Cell. 2016 May 23;37(4):362-376. doi: 10.1016/j.devcel.2016.04.024. Dev Cell. 2016. PMID: 27219064 Free PMC article.
GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses.
Kashyap AS, Fernandez-Rodriguez L, Zhao Y, Monaco G, Trefny MP, Yoshida N, Martin K, Sharma A, Olieric N, Shah P, Stanczak M, Kirchhammer N, Park SM, Wieckowski S, Laubli H, Zagani R, Kasenda B, Steinmetz MO, Reinecker HC, Zippelius A. Kashyap AS, et al. Among authors: sharma a. Cell Rep. 2019 Sep 24;28(13):3367-3380.e8. doi: 10.1016/j.celrep.2019.08.057. Cell Rep. 2019. PMID: 31553907 Free PMC article.
Inhibiting parasite proliferation using a rationally designed anti-tubulin agent.
Gaillard N, Sharma A, Abbaali I, Liu T, Shilliday F, Cook AD, Ehrhard V, Bangera M, Roberts AJ, Moores CA, Morrissette N, Steinmetz MO. Gaillard N, et al. Among authors: sharma a. EMBO Mol Med. 2021 Nov 8;13(11):e13818. doi: 10.15252/emmm.202013818. Epub 2021 Oct 18. EMBO Mol Med. 2021. PMID: 34661376 Free PMC article.
Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies.
Burger D, Stihle M, Sharma A, Di Lello P, Benz J, D'Arcy B, Debulpaep M, Fry D, Huber W, Kremer T, Laeremans T, Matile H, Ross A, Rufer AC, Schoch G, Steinmetz MO, Steyaert J, Rudolph MG, Thoma R, Ruf A. Burger D, et al. Among authors: sharma a. J Biol Chem. 2016 Jul 29;291(31):16292-306. doi: 10.1074/jbc.M116.726547. Epub 2016 May 10. J Biol Chem. 2016. PMID: 27226599 Free PMC article.
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