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10,558 results
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In vitro screening techniques for reactive metabolites for minimizing bioactivation potential in drug discovery.
Prakash C, Sharma R, Gleave M, Nedderman A. Prakash C, et al. Among authors: sharma r. Curr Drug Metab. 2008 Nov;9(9):952-64. doi: 10.2174/138920008786485209. Curr Drug Metab. 2008. PMID: 18991592
Differences in CYP3A4 catalyzed bioactivation of 5-aminooxindole and 5-aminobenzsultam scaffolds in proline-rich tyrosine kinase 2 (PYK2) inhibitors: retrospective analysis by CYP3A4 molecular docking, quantum chemical calculations and glutathione adduct detection using linear ion trap/orbitrap mass spectrometry.
Sun H, Sharma R, Bauman J, Walker DP, Aspnes GE, Zawistoski MP, Kalgutkar AS. Sun H, et al. Among authors: sharma r. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3177-82. doi: 10.1016/j.bmcl.2009.04.118. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19433356
The use of 18O-exchange and base-catalyzed N-dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites.
Bessire AJ, Vaz AD, Walker GS, Wang WW, Sharma R. Bessire AJ, et al. Among authors: sharma r. Rapid Commun Mass Spectrom. 2010 Jul 30;24(14):2151-61. doi: 10.1002/rcm.4595. Rapid Commun Mass Spectrom. 2010. PMID: 20552706
A rapid and specific derivatization procedure to identify acyl-glucuronides by mass spectrometry.
Vaz AD, Wang WW, Bessire AJ, Sharma R, Hagen AE. Vaz AD, et al. Among authors: sharma r. Rapid Commun Mass Spectrom. 2010 Jul 30;24(14):2109-21. doi: 10.1002/rcm.4621. Rapid Commun Mass Spectrom. 2010. PMID: 20552710
Validation of isolated metabolites from drug metabolism studies as analytical standards by quantitative NMR.
Walker GS, Ryder TF, Sharma R, Smith EB, Freund A. Walker GS, et al. Among authors: sharma r. Drug Metab Dispos. 2011 Mar;39(3):433-40. doi: 10.1124/dmd.110.036343. Epub 2010 Nov 22. Drug Metab Dispos. 2011. PMID: 21098098
Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma.
Sharma R, Eng H, Walker GS, Barreiro G, Stepan AF, McClure KF, Wolford A, Bonin PD, Cornelius P, Kalgutkar AS. Sharma R, et al. Chem Res Toxicol. 2011 Dec 19;24(12):2207-16. doi: 10.1021/tx200329k. Epub 2011 Oct 4. Chem Res Toxicol. 2011. PMID: 21939274
Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs.
Sharma R, Strelevitz TJ, Gao H, Clark AJ, Schildknegt K, Obach RS, Ripp SL, Spracklin DK, Tremaine LM, Vaz AD. Sharma R, et al. Drug Metab Dispos. 2012 Mar;40(3):625-34. doi: 10.1124/dmd.111.042770. Epub 2011 Dec 21. Drug Metab Dispos. 2012. PMID: 22190693
Immune-mediated agranulocytosis caused by the cocaine adulterant levamisole: a case for reactive metabolite(s) involvement.
Wolford A, McDonald TS, Eng H, Hansel S, Chen Y, Bauman J, Sharma R, Kalgutkar AS. Wolford A, et al. Among authors: sharma r. Drug Metab Dispos. 2012 Jun;40(6):1067-75. doi: 10.1124/dmd.112.045021. Epub 2012 Mar 5. Drug Metab Dispos. 2012. PMID: 22393119 Review.
Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human.
Sharma R, Sun H, Piotrowski DW, Ryder TF, Doran SD, Dai H, Prakash C. Sharma R, et al. Drug Metab Dispos. 2012 Nov;40(11):2143-61. doi: 10.1124/dmd.112.047316. Epub 2012 Aug 15. Drug Metab Dispos. 2012. PMID: 22896728
Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects.
Miao Z, Nucci G, Amin N, Sharma R, Mascitti V, Tugnait M, Vaz AD, Callegari E, Kalgutkar AS. Miao Z, et al. Among authors: sharma r. Drug Metab Dispos. 2013 Feb;41(2):445-56. doi: 10.1124/dmd.112.049551. Epub 2012 Nov 20. Drug Metab Dispos. 2013. PMID: 23169609 Clinical Trial.
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