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Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia.
McAllister F, Bailey JM, Alsina J, Nirschl CJ, Sharma R, Fan H, Rattigan Y, Roeser JC, Lankapalli RH, Zhang H, Jaffee EM, Drake CG, Housseau F, Maitra A, Kolls JK, Sears CL, Pardoll DM, Leach SD. McAllister F, et al. Among authors: sharma r. Cancer Cell. 2014 May 12;25(5):621-37. doi: 10.1016/j.ccr.2014.03.014. Cancer Cell. 2014. PMID: 24823639 Free PMC article.
Dual Inhibition of Hedgehog and c-Met Pathways for Pancreatic Cancer Treatment.
Rucki AA, Xiao Q, Muth S, Chen J, Che X, Kleponis J, Sharma R, Anders RA, Jaffee EM, Zheng L. Rucki AA, et al. Among authors: sharma r. Mol Cancer Ther. 2017 Nov;16(11):2399-2409. doi: 10.1158/1535-7163.MCT-16-0452. Epub 2017 Sep 1. Mol Cancer Ther. 2017. PMID: 28864680 Free PMC article.
Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation.
Lutz ER, Wu AA, Bigelow E, Sharma R, Mo G, Soares K, Solt S, Dorman A, Wamwea A, Yager A, Laheru D, Wolfgang CL, Wang J, Hruban RH, Anders RA, Jaffee EM, Zheng L. Lutz ER, et al. Among authors: sharma r. Cancer Immunol Res. 2014 Jul;2(7):616-31. doi: 10.1158/2326-6066.CIR-14-0027. Epub 2014 Jun 18. Cancer Immunol Res. 2014. PMID: 24942756 Free PMC article. Clinical Trial.
Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer.
Jhaveri DT, Kim MS, Thompson ED, Huang L, Sharma R, Klein AP, Zheng L, Le DT, Laheru DA, Pandey A, Jaffee EM, Anders RA. Jhaveri DT, et al. Among authors: sharma r. Cancer Immunol Res. 2016 Mar;4(3):225-33. doi: 10.1158/2326-6066.CIR-15-0200-T. Epub 2016 Feb 3. Cancer Immunol Res. 2016. PMID: 26842750 Free PMC article.
Characterization of the Immune Microenvironment in Hepatocellular Carcinoma.
Yarchoan M, Xing D, Luan L, Xu H, Sharma RB, Popovic A, Pawlik TM, Kim AK, Zhu Q, Jaffee EM, Taube JM, Anders RA. Yarchoan M, et al. Clin Cancer Res. 2017 Dec 1;23(23):7333-7339. doi: 10.1158/1078-0432.CCR-17-0950. Epub 2017 Sep 19. Clin Cancer Res. 2017. PMID: 28928158 Free PMC article.
Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells.
Salaria SN, Illei P, Sharma R, Walter KM, Klein AP, Eshleman JR, Maitra A, Schulick R, Winter J, Ouellette MM, Goggins M, Hruban R. Salaria SN, et al. Among authors: sharma r. Cancer Biol Ther. 2007 Mar;6(3):324-8. doi: 10.4161/cbt.6.3.3904. Epub 2007 Mar 24. Cancer Biol Ther. 2007. PMID: 17404500 Free PMC article.
An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.
Feldmann G, Fendrich V, McGovern K, Bedja D, Bisht S, Alvarez H, Koorstra JB, Habbe N, Karikari C, Mullendore M, Gabrielson KL, Sharma R, Matsui W, Maitra A. Feldmann G, et al. Among authors: sharma r. Mol Cancer Ther. 2008 Sep;7(9):2725-35. doi: 10.1158/1535-7163.MCT-08-0573. Mol Cancer Ther. 2008. PMID: 18790753 Free PMC article.
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