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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.
Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nuñez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA. Masters SL, et al. Among authors: sharp fa. Nat Immunol. 2010 Oct;11(10):897-904. doi: 10.1038/ni.1935. Epub 2010 Sep 12. Nat Immunol. 2010. PMID: 20835230 Free PMC article.
Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation.
Harris J, Hartman M, Roche C, Zeng SG, O'Shea A, Sharp FA, Lambe EM, Creagh EM, Golenbock DT, Tschopp J, Kornfeld H, Fitzgerald KA, Lavelle EC. Harris J, et al. Among authors: sharp fa. J Biol Chem. 2011 Mar 18;286(11):9587-97. doi: 10.1074/jbc.M110.202911. Epub 2011 Jan 12. J Biol Chem. 2011. PMID: 21228274 Free PMC article.
Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles.
Muñoz-Wolf N, Ward RW, Hearnden CH, Sharp FA, Geoghegan J, O'Grady K, McEntee CP, Shanahan KA, Guy C, Bowie AG, Campbell M, Roces CB, Anderluzzi G, Webb C, Perrie Y, Creagh E, Lavelle EC. Muñoz-Wolf N, et al. Among authors: sharp fa. Cell Rep Med. 2023 Jan 17;4(1):100899. doi: 10.1016/j.xcrm.2022.100899. Cell Rep Med. 2023. PMID: 36652908 Free PMC article.
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