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The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses.
Mori A, Oleszycka E, Sharp FA, Coleman M, Ozasa Y, Singh M, O'Hagan DT, Tajber L, Corrigan OI, McNeela EA, Lavelle EC. Mori A, et al. Among authors: sharp fa. Eur J Immunol. 2012 Oct;42(10):2709-19. doi: 10.1002/eji.201242372. Epub 2012 Aug 6. Eur J Immunol. 2012. PMID: 22777876 Free article.
The vaccine adjuvant alum promotes IL-10 production that suppresses Th1 responses.
Oleszycka E, McCluskey S, Sharp FA, Muñoz-Wolf N, Hams E, Gorman AL, Fallon PG, Lavelle EC. Oleszycka E, et al. Among authors: sharp fa. Eur J Immunol. 2018 Apr;48(4):705-715. doi: 10.1002/eji.201747150. Epub 2018 Feb 15. Eur J Immunol. 2018. PMID: 29349774 Free article.
Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation.
Harris J, Hartman M, Roche C, Zeng SG, O'Shea A, Sharp FA, Lambe EM, Creagh EM, Golenbock DT, Tschopp J, Kornfeld H, Fitzgerald KA, Lavelle EC. Harris J, et al. Among authors: sharp fa. J Biol Chem. 2011 Mar 18;286(11):9587-97. doi: 10.1074/jbc.M110.202911. Epub 2011 Jan 12. J Biol Chem. 2011. PMID: 21228274 Free PMC article.
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.
Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nuñez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA. Masters SL, et al. Among authors: sharp fa. Nat Immunol. 2010 Oct;11(10):897-904. doi: 10.1038/ni.1935. Epub 2010 Sep 12. Nat Immunol. 2010. PMID: 20835230 Free PMC article.
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome.
Sharp FA, Ruane D, Claass B, Creagh E, Harris J, Malyala P, Singh M, O'Hagan DT, Pétrilli V, Tschopp J, O'Neill LA, Lavelle EC. Sharp FA, et al. Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):870-5. doi: 10.1073/pnas.0804897106. Epub 2009 Jan 12. Proc Natl Acad Sci U S A. 2009. PMID: 19139407 Free PMC article.
Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines.
Demento SL, Siefert AL, Bandyopadhyay A, Sharp FA, Fahmy TM. Demento SL, et al. Among authors: sharp fa. Trends Biotechnol. 2011 Jun;29(6):294-306. doi: 10.1016/j.tibtech.2011.02.004. Epub 2011 Apr 2. Trends Biotechnol. 2011. PMID: 21459467 Free PMC article. Review.
Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen.
Saluja SS, Hanlon DJ, Sharp FA, Hong E, Khalil D, Robinson E, Tigelaar R, Fahmy TM, Edelson RL. Saluja SS, et al. Among authors: sharp fa. Int J Nanomedicine. 2014 Nov 12;9:5231-46. doi: 10.2147/IJN.S66639. eCollection 2014. Int J Nanomedicine. 2014. PMID: 25419128 Free PMC article.
A carbon nanotube-polymer composite for T-cell therapy.
Fadel TR, Sharp FA, Vudattu N, Ragheb R, Garyu J, Kim D, Hong E, Li N, Haller GL, Pfefferle LD, Justesen S, Herold KC, Fahmy TM. Fadel TR, et al. Among authors: sharp fa. Nat Nanotechnol. 2014 Aug;9(8):639-47. doi: 10.1038/nnano.2014.154. Epub 2014 Aug 3. Nat Nanotechnol. 2014. PMID: 25086604
Dosimeter for oxides of nitrogen.
Ferber BI, Sharp FA, Freedman RW. Ferber BI, et al. Among authors: sharp fa. Am Ind Hyg Assoc J. 1976 Jan;37(1):32-6. doi: 10.1080/0002889768507404. Am Ind Hyg Assoc J. 1976. PMID: 1246946
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