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T Cell Activation Depends on Extracellular Alanine.
Ron-Harel N, Ghergurovich JM, Notarangelo G, LaFleur MW, Tsubosaka Y, Sharpe AH, Rabinowitz JD, Haigis MC. Ron-Harel N, et al. Among authors: sharpe ah. Cell Rep. 2019 Sep 17;28(12):3011-3021.e4. doi: 10.1016/j.celrep.2019.08.034. Cell Rep. 2019. PMID: 31533027 Free PMC article.
CTLA-4 and T cell activation.
Oosterwegel MA, Greenwald RJ, Mandelbrot DA, Lorsbach RB, Sharpe AH. Oosterwegel MA, et al. Among authors: sharpe ah. Curr Opin Immunol. 1999 Jun;11(3):294-300. doi: 10.1016/s0952-7915(99)80047-8. Curr Opin Immunol. 1999. PMID: 10375557 Review.
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC. Laurent G, et al. Among authors: sharpe ah. Mol Cell. 2013 Jun 6;50(5):686-98. doi: 10.1016/j.molcel.2013.05.012. Mol Cell. 2013. PMID: 23746352 Free PMC article.
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.
Manguso RT, Pope HW, Zimmer MD, Brown FD, Yates KB, Miller BC, Collins NB, Bi K, LaFleur MW, Juneja VR, Weiss SA, Lo J, Fisher DE, Miao D, Van Allen E, Root DE, Sharpe AH, Doench JG, Haining WN. Manguso RT, et al. Among authors: sharpe ah. Nature. 2017 Jul 27;547(7664):413-418. doi: 10.1038/nature23270. Epub 2017 Jul 19. Nature. 2017. PMID: 28723893 Free PMC article.
Inhibitors of the PD-1 Pathway in Tumor Therapy.
LaFleur MW, Muroyama Y, Drake CG, Sharpe AH. LaFleur MW, et al. Among authors: sharpe ah. J Immunol. 2018 Jan 15;200(2):375-383. doi: 10.4049/jimmunol.1701044. J Immunol. 2018. PMID: 29311378 Free PMC article. Review.
422 results