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A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.
Rostovtsev VV, Green LG, Fokin VV, Sharpless KB. Rostovtsev VV, et al. Angew Chem Int Ed Engl. 2002 Jul 15;41(14):2596-9. doi: 10.1002/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4. Angew Chem Int Ed Engl. 2002. PMID: 12203546 No abstract available.
Click Chemistry: Diverse Chemical Function from a Few Good Reactions.
Kolb HC, Finn MG, Sharpless KB. Kolb HC, et al. Angew Chem Int Ed Engl. 2001 Jun 1;40(11):2004-2021. doi: 10.1002/1521-3773(20010601)40:11<2004::aid-anie2004>;2-x. Angew Chem Int Ed Engl. 2001. PMID: 11433435
An expedient route to the tetrazole analogues of alpha-amino acids.
Demko ZP, Sharpless KB. Demko ZP, et al. Org Lett. 2002 Jul 25;4(15):2525-7. doi: 10.1021/ol020096x. Org Lett. 2002. PMID: 12123367
Mechanisms of tetrazole formation by addition of azide to nitriles.
Himo F, Demko ZP, Noodleman L, Sharpless KB. Himo F, et al. J Am Chem Soc. 2002 Oct 16;124(41):12210-6. doi: 10.1021/ja0206644. J Am Chem Soc. 2002. PMID: 12371861
Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks.
Lewis WG, Green LG, Grynszpan F, Radić Z, Carlier PR, Taylor P, Finn MG, Sharpless KB. Lewis WG, et al. Angew Chem Int Ed Engl. 2002 Mar 15;41(6):1053-7. doi: 10.1002/1521-3773(20020315)41:6<1053::aid-anie1053>;2-4. Angew Chem Int Ed Engl. 2002. PMID: 12491310 No abstract available.
A new approach to osmium-catalyzed asymmetric dihydroxylation and aminohydroxylation of olefins.
Andersson MA, Epple R, Fokin VV, Sharpless KB. Andersson MA, et al. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):472-5. doi: 10.1002/1521-3773(20020201)41:3<472::aid-anie472>;2-7. Angew Chem Int Ed Engl. 2002. PMID: 12491382 No abstract available.
Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition.
Wang Q, Chan TR, Hilgraf R, Fokin VV, Sharpless KB, Finn MG. Wang Q, et al. J Am Chem Soc. 2003 Mar 19;125(11):3192-3. doi: 10.1021/ja021381e. J Am Chem Soc. 2003. PMID: 12630856
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