Sharrow SO - Search Results

1

Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.

Tai X, Van Laethem F, Pobezinsky L, Guinter T, Sharrow SO, Adams A, Granger L, Kruhlak M, Lindsten T, Thompson CB, Feigenbaum L, Singer A. Tai X, et al. Among authors: sharrow so. Blood. 2012 May 31;119(22):5155-63. doi: 10.1182/blood-2011-11-388918. Epub 2012 Mar 7. Blood. 2012. PMID: 22403258 Free PMC article.

2

Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.

Erman B, Alag AS, Dahle O, van Laethem F, Sarafova SD, Guinter TI, Sharrow SO, Grinberg A, Love PE, Singer A. Erman B, et al. Among authors: sharrow so. J Immunol. 2006 Nov 15;177(10):6613-25. doi: 10.4049/jimmunol.177.10.6613. J Immunol. 2006. PMID: 17082573

3

Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.

Van Laethem F, Sarafova SD, Park JH, Tai X, Pobezinsky L, Guinter TI, Adoro S, Adams A, Sharrow SO, Feigenbaum L, Singer A. Van Laethem F, et al. Among authors: sharrow so. Immunity. 2007 Nov;27(5):735-50. doi: 10.1016/j.immuni.2007.10.007. Immunity. 2007. PMID: 18023370 Free article.

4

Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.

Sarafova SD, Van Laethem F, Adoro S, Guinter T, Sharrow SO, Feigenbaum L, Singer A. Sarafova SD, et al. Among authors: sharrow so. Immunity. 2009 Sep 18;31(3):480-90. doi: 10.1016/j.immuni.2009.07.006. Epub 2009 Sep 10. Immunity. 2009. PMID: 19747858 Free PMC article.

5

Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.

Van Laethem F, Tikhonova AN, Pobezinsky LA, Tai X, Kimura MY, Le Saout C, Guinter TI, Adams A, Sharrow SO, Bernhardt G, Feigenbaum L, Singer A. Van Laethem F, et al. Among authors: sharrow so. Cell. 2013 Sep 12;154(6):1326-41. doi: 10.1016/j.cell.2013.08.009. Cell. 2013. PMID: 24034254 Free PMC article.

6

Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.

Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ. Williams JA, et al. Among authors: sharrow so. J Immunol. 2014 Jan 15;192(2):630-40. doi: 10.4049/jimmunol.1302550. Epub 2013 Dec 13. J Immunol. 2014. PMID: 24337745 Free PMC article.

7

Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells.

Bosselut R, Guinter TI, Sharrow SO, Singer A. Bosselut R, et al. Among authors: sharrow so. J Exp Med. 2003 Jun 16;197(12):1709-19. doi: 10.1084/jem.20030170. J Exp Med. 2003. PMID: 12810689 Free PMC article.

8

Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.

Sarafova SD, Erman B, Yu Q, Van Laethem F, Guinter T, Sharrow SO, Feigenbaum L, Wildt KF, Ellmeier W, Singer A. Sarafova SD, et al. Among authors: sharrow so. Immunity. 2005 Jul;23(1):75-87. doi: 10.1016/j.immuni.2005.05.011. Immunity. 2005. PMID: 16039581 Free article.

9

Disruption of intrathymic CD4-Ia interactions on immature CD4+CD8+ thymocytes results in diminished TCR expression on mature CD8+ T cell progeny.

Roberts JL, Sharrow SO, Singer A. Roberts JL, et al. Among authors: sharrow so. Cell Immunol. 1995 Mar;161(1):22-7. doi: 10.1006/cimm.1995.1004. Cell Immunol. 1995. PMID: 7867081

10

Lineage commitment in the thymus: only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis.

Punt JA, Suzuki H, Granger LG, Sharrow SO, Singer A. Punt JA, et al. Among authors: sharrow so. J Exp Med. 1996 Dec 1;184(6):2091-9. doi: 10.1084/jem.184.6.2091. J Exp Med. 1996. PMID: 8976166 Free PMC article.

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