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Thrombosis in the uremic milieu--emerging role of "thrombolome".
Shashar M, Francis J, Chitalia V. Shashar M, et al. Semin Dial. 2015 Mar-Apr;28(2):198-205. doi: 10.1111/sdi.12255. Epub 2014 Jun 24. Semin Dial. 2015. PMID: 24962903 Free PMC article. Review.
Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk.
Shashar M, Belghasem ME, Matsuura S, Walker J, Richards S, Alousi F, Rijal K, Kolachalama VB, Balcells M, Odagi M, Nagasawa K, Henderson JM, Gautam A, Rushmore R, Francis J, Kirchhofer D, Kolandaivelu K, Sherr DH, Edelman ER, Ravid K, Chitalia VC. Shashar M, et al. Sci Transl Med. 2017 Nov 22;9(417):eaam8475. doi: 10.1126/scitranslmed.aam8475. Sci Transl Med. 2017. PMID: 29167396 Free PMC article.
The Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an Antithrombotic Target in Uremia.
Shivanna S, Kolandaivelu K, Shashar M, Belghasim M, Al-Rabadi L, Balcells M, Zhang A, Weinberg J, Francis J, Pollastri MP, Edelman ER, Sherr DH, Chitalia VC. Shivanna S, et al. Among authors: shashar m. J Am Soc Nephrol. 2016 Jan;27(1):189-201. doi: 10.1681/ASN.2014121241. Epub 2015 May 27. J Am Soc Nephrol. 2016. PMID: 26019318 Free PMC article.
Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans.
Kolachalama VB, Shashar M, Alousi F, Shivanna S, Rijal K, Belghasem ME, Walker J, Matsuura S, Chang GH, Gibson CM, Dember LM, Francis JM, Ravid K, Chitalia VC. Kolachalama VB, et al. Among authors: shashar m. J Am Soc Nephrol. 2018 Mar;29(3):1063-1072. doi: 10.1681/ASN.2017080929. Epub 2018 Jan 17. J Am Soc Nephrol. 2018. PMID: 29343519 Free PMC article.
c-Cbl mediates the degradation of tumorigenic nuclear β-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors.
Shashar M, Siwak J, Tapan U, Lee SY, Meyer RD, Parrack P, Tan J, Khatami F, Francis J, Zhao Q, Hartshorn K, Kolachalama VB, Rahimi N, Chitalia V. Shashar M, et al. Oncotarget. 2016 Nov 1;7(44):71136-71150. doi: 10.18632/oncotarget.12107. Oncotarget. 2016. PMID: 27661103 Free PMC article.
Cyclosporine attenuates arginine transport, in human endothelial cells, through modulation of cationic amino acid transporter-1.
Grupper A, Shashar M, Bahry D, Pri-Paz Y, Ben Tur O, Levi S, Chernichovski T, Chernin G, Schwartz IF. Grupper A, et al. Among authors: shashar m. Am J Nephrol. 2013;37(6):613-9. doi: 10.1159/000350614. Epub 2013 Jun 13. Am J Nephrol. 2013. PMID: 23796541
The c-Cbl ubiquitin ligase regulates nuclear β-catenin and angiogenesis by its tyrosine phosphorylation mediated through the Wnt signaling pathway.
Shivanna S, Harrold I, Shashar M, Meyer R, Kiang C, Francis J, Zhao Q, Feng H, Edelman ER, Rahimi N, Chitalia VC. Shivanna S, et al. Among authors: shashar m. J Biol Chem. 2015 May 15;290(20):12537-46. doi: 10.1074/jbc.M114.616623. Epub 2015 Mar 17. J Biol Chem. 2015. PMID: 25784557 Free PMC article.
Concurrent Presentation of Thrombotic Thrombocytopenic Purpura and Membranous Nephropathy.
Al-Rabadi L, Quillen K, Shashar M, Al Marji C, Jaberi A, Chitalia V, Henderson J, Salant D, Beck LH Jr. Al-Rabadi L, et al. Among authors: shashar m. Kidney Int Rep. 2017 Aug 19;3(2):476-481. doi: 10.1016/j.ekir.2017.08.005. eCollection 2018 Mar. Kidney Int Rep. 2017. PMID: 29725652 Free PMC article. No abstract available.
Profound Decrease in Glomerular Arginine Transport by CAT (Cationic Amino Acid Transporter)-1 Contributes to the FLT-1 (FMS-Like Tyrosine Kinase 1) Induced Preeclampsia in the Pregnant Mice.
Shashar M, Zubkov A, Chernichovski T, Hershkovitz R, Hoffman E, Grupper A, Weinstein T, Schwartz IF. Shashar M, et al. Hypertension. 2019 Apr;73(4):878-884. doi: 10.1161/HYPERTENSIONAHA.118.12372. Hypertension. 2019. PMID: 30798662
Long term metabolic and renal outcomes of kidney donors compared to controls with excellent kidney function.
Grupper A, Angel Y, Baruch A, Schwartz IF, Schwartz D, Nakache R, Goykhman Y, Katz P, Nachmany I, Lubezky N, Weinstein T, Shashar M, Ben-Bassat OK, Berliner S, Rogowski O, Zeltser D, Shapira I, Shenhar-Tsarfaty S. Grupper A, et al. Among authors: shashar m. BMC Nephrol. 2019 Jan 31;20(1):30. doi: 10.1186/s12882-019-1214-4. BMC Nephrol. 2019. PMID: 30704441 Free PMC article.
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