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Antibody responses after intravaginal immunisation with trimeric HIV-1 CN54 clade C gp140 in Carbopol gel are augmented by systemic priming or boosting with an adjuvanted formulation.
Cranage MP, Fraser CA, Cope A, McKay PF, Seaman MS, Cole T, Mahmoud AN, Hall J, Giles E, Voss G, Page M, Almond N, Shattock RJ. Cranage MP, et al. Among authors: shattock rj. Vaccine. 2011 Feb 4;29(7):1421-30. doi: 10.1016/j.vaccine.2010.12.034. Epub 2010 Dec 25. Vaccine. 2011. PMID: 21187177 Free PMC article.
Intravaginal immunization using the recombinant HIV-1 clade-C trimeric envelope glycoprotein CN54gp140 formulated within lyophilized solid dosage forms.
Donnelly L, Curran RM, Tregoning JS, McKay PF, Cole T, Morrow RJ, Kett VL, Andrews GP, Woolfson AD, Malcolm RK, Shattock RJ. Donnelly L, et al. Among authors: shattock rj. Vaccine. 2011 Jun 15;29(27):4512-20. doi: 10.1016/j.vaccine.2011.04.023. Epub 2011 Apr 21. Vaccine. 2011. PMID: 21514349 Free PMC article.
Phase I randomised clinical trial of an HIV-1(CN54), clade C, trimeric envelope vaccine candidate delivered vaginally.
Lewis DJ, Fraser CA, Mahmoud AN, Wiggins RC, Woodrow M, Cope A, Cai C, Giemza R, Jeffs SA, Manoussaka M, Cole T, Cranage MP, Shattock RJ, Lacey CJ. Lewis DJ, et al. Among authors: shattock rj. PLoS One. 2011;6(9):e25165. doi: 10.1371/journal.pone.0025165. Epub 2011 Sep 30. PLoS One. 2011. PMID: 21984924 Free PMC article. Clinical Trial.
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