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A major predisposition locus for severe obesity, at 4p15-p14.
Stone S, Abkevich V, Hunt SC, Gutin A, Russell DL, Neff CD, Riley R, Frech GC, Hensel CH, Jammulapati S, Potter J, Sexton D, Tran T, Gibbs D, Iliev D, Gress R, Bloomquist B, Amatruda J, Rae PM, Adams TD, Skolnick MH, Shattuck D. Stone S, et al. Am J Hum Genet. 2002 Jun;70(6):1459-68. doi: 10.1086/340670. Epub 2002 Apr 15. Am J Hum Genet. 2002. PMID: 11957135 Free PMC article.
Linkage of body mass index to chromosome 20 in Utah pedigrees.
Hunt SC, Abkevich V, Hensel CH, Gutin A, Neff CD, Russell DL, Tran T, Hong X, Jammulapati S, Riley R, Weaver-Feldhaus J, Macalma T, Richards MM, Gress R, Francis M, Thomas A, Frech GC, Adams TD, Shattuck D, Stone S. Hunt SC, et al. Hum Genet. 2001 Sep;109(3):279-85. doi: 10.1007/s004390100581. Hum Genet. 2001. PMID: 11702208
Predisposition locus for major depression at chromosome 12q22-12q23.2.
Abkevich V, Camp NJ, Hensel CH, Neff CD, Russell DL, Hughes DC, Plenk AM, Lowry MR, Richards RL, Carter C, Frech GC, Stone S, Rowe K, Chau CA, Cortado K, Hunt A, Luce K, O'Neil G, Poarch J, Potter J, Poulsen GH, Saxton H, Bernat-Sestak M, Thompson V, Gutin A, Skolnick MH, Shattuck D, Cannon-Albright L. Abkevich V, et al. Am J Hum Genet. 2003 Dec;73(6):1271-81. doi: 10.1086/379978. Epub 2003 Nov 5. Am J Hum Genet. 2003. PMID: 14606042 Free PMC article.
Genome-wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early-onset major depression and anxiety disorders.
Camp NJ, Lowry MR, Richards RL, Plenk AM, Carter C, Hensel CH, Abkevich V, Skolnick MH, Shattuck D, Rowe KG, Hughes DC, Cannon-Albright LA. Camp NJ, et al. Am J Med Genet B Neuropsychiatr Genet. 2005 May 5;135B(1):85-93. doi: 10.1002/ajmg.b.30177. Am J Med Genet B Neuropsychiatr Genet. 2005. PMID: 15806581
Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression.
Neff CD, Abkevich V, Packer JC, Chen Y, Potter J, Riley R, Davenport C, DeGrado Warren J, Jammulapati S, Bhathena A, Choi WS, Kroeger PE, Metzger RE, Gutin A, Skolnick MH, Shattuck D, Katz DA. Neff CD, et al. Mol Psychiatry. 2009 Jun;14(6):621-30. doi: 10.1038/mp.2008.8. Epub 2008 Feb 12. Mol Psychiatry. 2009. PMID: 18268499
Variants in Apaf-1 segregating with major depression promote apoptosome function.
Harlan J, Chen Y, Gubbins E, Mueller R, Roch JM, Walter K, Lake M, Olsen T, Metzger P, Dorwin S, Ladror U, Egan DA, Severin J, Johnson RW, Holzman TF, Voelp K, Davenport C, Beck A, Potter J, Gopalakrishnan M, Hahn A, Spear BB, Halbert DN, Sullivan JP, Abkevich V, Neff CD, Skolnick MH, Shattuck D, Katz DA. Harlan J, et al. Mol Psychiatry. 2006 Jan;11(1):76-85. doi: 10.1038/sj.mp.4001755. Mol Psychiatry. 2006. PMID: 16231040
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