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1,25-dihydroxyvitamin D3 regulates pp60c-src activity and expression of a pp60c-src activating phosphatase.
Chappel J, Ross FP, Abu-Amer Y, Shaw A, Teitelbaum SL. Chappel J, et al. J Cell Biochem. 1997 Dec 15;67(4):432-8. doi: 10.1002/(sici)1097-4644(19971215)67:4<432::aid-jcb2>3.0.co;2-t. J Cell Biochem. 1997. PMID: 9383703
On the other hand, functional relationships between the activities of c-src and 1,25(OH)2D3 are as yet unknown. To determine if 1,25(OH)2D3 modulates c-src in osteoclastogenesis, we tested the steroid's effect on avian marrow-derived osteoclast precursors. ...
On the other hand, functional relationships between the activities of c-src and 1,25(OH)2D3 are as yet unknown. To determine if 1,25( …
Nuclear localization of the PEP protein tyrosine phosphatase.
Flores E, Roy G, Patel D, Shaw A, Thomas ML. Flores E, et al. Mol Cell Biol. 1994 Jul;14(7):4938-46. doi: 10.1128/mcb.14.7.4938. Mol Cell Biol. 1994. PMID: 7516475 Free PMC article.
The 14-3-3 proteins.
Shaw A. Shaw A. Curr Biol. 2000 Jun 1;10(11):R400. doi: 10.1016/s0960-9822(00)00519-4. Curr Biol. 2000. PMID: 10837257 No abstract available.
Allosteric activation of functionally asymmetric RAF kinase dimers.
Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJS, Kornev AP, Taylor SS, Shaw AS. Hu J, et al. Cell. 2013 Aug 29;154(5):1036-1046. doi: 10.1016/j.cell.2013.07.046. Cell. 2013. PMID: 23993095 Free PMC article.
Here we show that the dimer is functionally asymmetric with one kinase functioning as an activator to stimulate activity of the partner, receiver kinase. ...As N-terminal phosphorylation of BRAF is constitutive, BRAF initially functions to activate CRAF. N-terminal …
Here we show that the dimer is functionally asymmetric with one kinase functioning as an activator to stimulate activity of the partn …
Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF.
Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS. Hu J, et al. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6067-72. doi: 10.1073/pnas.1102554108. Epub 2011 Mar 25. Proc Natl Acad Sci U S A. 2011. PMID: 21441104 Free PMC article.
Not only does this work suggest that KSR1 may function as a kinase, we anticipate that the mutation that we generated may be broadly applicable to stabilize the closed conformation of other kinases many of which may also form dimers....
Not only does this work suggest that KSR1 may function as a kinase, we anticipate that the mutation that we generated may be broadly …
Kinase regulation by hydrophobic spine assembly in cancer.
Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor SS, Shaw AS. Hu J, et al. Mol Cell Biol. 2015 Jan;35(1):264-76. doi: 10.1128/MCB.00943-14. Epub 2014 Oct 27. Mol Cell Biol. 2015. PMID: 25348715 Free PMC article.
This supports the key role of the C-helix as a signal integration motif for coordinating multiple elements of the kinase to create an active conformation. ...
This supports the key role of the C-helix as a signal integration motif for coordinating multiple elements of the kinase to create an …
Kinases and pseudokinases: lessons from RAF.
Shaw AS, Kornev AP, Hu J, Ahuja LG, Taylor SS. Shaw AS, et al. Mol Cell Biol. 2014 May;34(9):1538-46. doi: 10.1128/MCB.00057-14. Epub 2014 Feb 24. Mol Cell Biol. 2014. PMID: 24567368 Free PMC article. Review.
Its first role is that of a signaling enzyme (classical kinases; canonical), while its second role is that of an allosteric activator of other kinases or as a scaffold protein for signaling in a manner that is independent of phosphoryl transfer (classical pseudokinases; no …
Its first role is that of a signaling enzyme (classical kinases; canonical), while its second role is that of an allosteric activator of oth …
Regulated movement of CD4 in and out of the immunological synapse.
Kao H, Lin J, Littman DR, Shaw AS, Allen PM. Kao H, et al. J Immunol. 2008 Dec 15;181(12):8248-57. doi: 10.4049/jimmunol.181.12.8248. J Immunol. 2008. PMID: 19050241 Free PMC article.
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