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Ras, PI(3)K and mTOR signalling controls tumour cell growth.
Shaw RJ, Cantley LC. Shaw RJ, et al. Nature. 2006 May 25;441(7092):424-30. doi: 10.1038/nature04869. Nature. 2006. PMID: 16724053 Review.
The LKB1 tumor suppressor negatively regulates mTOR signaling.
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. Shaw RJ, et al. Cancer Cell. 2004 Jul;6(1):91-9. doi: 10.1016/j.ccr.2004.06.007. Cancer Cell. 2004. PMID: 15261145
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. Shaw RJ, et al. Science. 2005 Dec 9;310(5754):1642-6. doi: 10.1126/science.1120781. Epub 2005 Nov 24. Science. 2005. PMID: 16308421 Free PMC article.
Glucose metabolism and cancer.
Shaw RJ. Shaw RJ. Curr Opin Cell Biol. 2006 Dec;18(6):598-608. doi: 10.1016/j.ceb.2006.10.005. Epub 2006 Oct 12. Curr Opin Cell Biol. 2006. PMID: 17046224 Review.
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. Gwinn DM, et al. Among authors: shaw rj. Mol Cell. 2008 Apr 25;30(2):214-26. doi: 10.1016/j.molcel.2008.03.003. Mol Cell. 2008. PMID: 18439900 Free PMC article.
AMPK and PPARdelta agonists are exercise mimetics.
Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM. Narkar VA, et al. Among authors: shaw rj. Cell. 2008 Aug 8;134(3):405-15. doi: 10.1016/j.cell.2008.06.051. Epub 2008 Jul 31. Cell. 2008. PMID: 18674809 Free PMC article.
mTOR signaling: RAG GTPases transmit the amino acid signal.
Shaw RJ. Shaw RJ. Trends Biochem Sci. 2008 Dec;33(12):565-8. doi: 10.1016/j.tibs.2008.09.005. Epub 2008 Oct 15. Trends Biochem Sci. 2008. PMID: 18929489 Free PMC article.
LKB1: cancer, polarity, metabolism, and now fertility.
Shaw RJ. Shaw RJ. Biochem J. 2008 Nov 15;416(1):e1-3. doi: 10.1042/BJ20082023. Biochem J. 2008. PMID: 18939946 Free PMC article.
Raptor swoops in on metabolism.
Shaw RJ. Shaw RJ. Cell Metab. 2008 Nov;8(5):343-4. doi: 10.1016/j.cmet.2008.10.007. Cell Metab. 2008. PMID: 19046565
Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans.
Mair W, Panowski SH, Shaw RJ, Dillin A. Mair W, et al. Among authors: shaw rj. PLoS One. 2009;4(2):e4535. doi: 10.1371/journal.pone.0004535. Epub 2009 Feb 20. PLoS One. 2009. PMID: 19229346 Free PMC article.
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