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Ileum-targeted steroid therapy in rheumatoid arthritis: double-blind, placebo-controlled trial of controlled-release budesonide.
Sheldon P. Sheldon P. Rheumatol Int. 2003 Jul;23(4):154-8. doi: 10.1007/s00296-002-0278-8. Epub 2003 Mar 6. Rheumatol Int. 2003. PMID: 12856138 Clinical Trial.
Evaluations were performed at 0, 2, and 4 weeks and included tender and swollen joint counts, duration of morning stiffness, visual analogue scale for pain (VAS) on a 100-mm horizontal scale, grip strength using a vigorimeter (lb/in(2)), haemoglobin, erythrocyte sedimentation rat …
Evaluations were performed at 0, 2, and 4 weeks and included tender and swollen joint counts, duration of morning stiffness, visual analogue …
Comparison of the effect of oral sulphasalazine, sulphapyridine and 5-amino-salicylic acid on the in vivo antibody response to oral and systemic antigen.
Sheldon P, Pell P. Sheldon P, et al. Br J Clin Pharmacol. 1993 Mar;35(3):261-4. doi: 10.1111/j.1365-2125.1993.tb05693.x. Br J Clin Pharmacol. 1993. PMID: 8097101 Free PMC article.
Sulphasalazine treated mice made less specific antibody of IgA class provided the antigen also was administered orally (P = 0.009 for days 7-28). ...The effect of sulphasalazine in this case was confined to the IgG response, which was significantly suppressed on day 28 ( …
Sulphasalazine treated mice made less specific antibody of IgA class provided the antigen also was administered orally (P = 0.009 for …
Comparison of the effects of sulphasalazine, 5-aminosalicylic acid and sulphapyridine on the humoral response to antigen in vivo.
Sheldon P, Pell P. Sheldon P, et al. Adv Exp Med Biol. 1995;371B:905-8. Adv Exp Med Biol. 1995. PMID: 7502923 No abstract available.
Rheumatoid arthritis and gut related lymphocytes: the iteropathy concept.
Sheldon P. Sheldon P. Ann Rheum Dis. 1988 Aug;47(8):697-700. doi: 10.1136/ard.47.8.697. Ann Rheum Dis. 1988. PMID: 3046519 Free PMC article. Review. No abstract available.
Effect of sulphasalazine on antibody response to oral antigen.
Sheldon P, Pell P, McBurney A. Sheldon P, et al. Br J Rheumatol. 1992 Dec;31(12):819-22. doi: 10.1093/rheumatology/31.12.819. Br J Rheumatol. 1992. PMID: 1360861

These were significant for IgA on day 21 (P = 0.013), and for days 7-28 (P = 0.009), and 14-28 (P = 0.007). Overall, considering all antibody classes together from day 7 to 28, there was a significant effect in the SASP treated group (P = < 0.04). .

These were significant for IgA on day 21 (P = 0.013), and for days 7-28 (P = 0.009), and 14-28 (P = 0.007). Overall, co …
Adhesion of rheumatoid peripheral blood and synovial fluid mononuclear cells to high endothelial venules of gut mucosa.
Kadioglu A, Sheldon P. Kadioglu A, et al. Among authors: sheldon p. Ann Rheum Dis. 1992 Jan;51(1):126-7. doi: 10.1136/ard.51.1.126. Ann Rheum Dis. 1992. PMID: 1540018 Free PMC article.
A randomised placebo controlled 12 week trial of budesonide and prednisolone in rheumatoid arthritis.
Kirwan JR, Hällgren R, Mielants H, Wollheim F, Bjorck E, Persson T, Book C, Bowman S, Byron M, Cox N, Field M, Kanerud L, Leirisalo-Repo M, Malaise M, Mohammad A, Palmer R, Petersson IF, Ringertz B, Sheldon P, Simonsson M, Snowden N, Van den Bosch F. Kirwan JR, et al. Among authors: sheldon p. Ann Rheum Dis. 2004 Jun;63(6):688-95. doi: 10.1136/ard.2003.008573. Ann Rheum Dis. 2004. PMID: 15140776 Free PMC article. Clinical Trial.
RESULTS: There were improvements in tender joint count and swollen joint count on budesonide 9 mg compared with placebo (28% for tender and 34% for swollen joint counts, p<0.05). ...
RESULTS: There were improvements in tender joint count and swollen joint count on budesonide 9 mg compared with placebo (28% for tender and …
Studies on synovial fluid lymphocytes in rheumatoid arthritis.
Holborow EJ, Sheldon PJ, Papamichail M. Holborow EJ, et al. Among authors: sheldon pj. Rheumatology. 1975;6:215-8. Rheumatology. 1975. PMID: 1081727 No abstract available.
Sulphasalazine therapy in rheumatoid arthritis: qualitative changes in lymphocytes and correlation with clinical response.
Samanta A, Webb C, Grindulis KA, Fleming J, Sheldon PJ. Samanta A, et al. Among authors: sheldon pj. Br J Rheumatol. 1992 Apr;31(4):259-63. doi: 10.1093/rheumatology/31.4.259. Br J Rheumatol. 1992. PMID: 1348199
Effect of sulphasalazine and its metabolites on mitogen induced transformation of lymphocytes--clues to its clinical action?
Sheldon P, Webb C, Grindulis KA. Sheldon P, et al. Br J Rheumatol. 1988 Oct;27(5):344-9. doi: 10.1093/rheumatology/27.5.344. Br J Rheumatol. 1988. PMID: 2902897
SASP exhibited a significant degree of suppression, at doses in the range 25-100 micrograms/ml (p less than 0.01), this suppression being greater than 50% at 50 micrograms/ml. SP exhibited only a minor degree of suppression (10% at 75 micrograms/ml, p less than 0.01 …
SASP exhibited a significant degree of suppression, at doses in the range 25-100 micrograms/ml (p less than 0.01), this suppression b …
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