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Bronchial aspirin challenge causes specific eicosanoid response in aspirin-sensitive asthmatics.
Szczeklik A, Sladek K, Dworski R, Nizankowska E, Soja J, Sheller J, Oates J. Szczeklik A, et al. Among authors: sheller j. Am J Respir Crit Care Med. 1996 Dec;154(6 Pt 1):1608-14. doi: 10.1164/ajrccm.154.6.8970343. Am J Respir Crit Care Med. 1996. PMID: 8970343
The prostaglandin E agonist, misoprostol, inhibits airway IL-5 production in atopic asthmatics.
Sheller J, Dworski R, Hagaman D, Oates J, Murray J. Sheller J, et al. Prostaglandins Other Lipid Mediat. 2002 Sep;70(1-2):185-93. doi: 10.1016/s0090-6980(02)00065-5. Prostaglandins Other Lipid Mediat. 2002. PMID: 12428688 Clinical Trial.
Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice.
Peebles RS Jr, Hashimoto K, Morrow JD, Dworski R, Collins RD, Hashimoto Y, Christman JW, Kang KH, Jarzecka K, Furlong J, Mitchell DB, Talati M, Graham BS, Sheller JR. Peebles RS Jr, et al. Among authors: sheller jr. Am J Respir Crit Care Med. 2002 Apr 15;165(8):1154-60. doi: 10.1164/ajrccm.165.8.2106025. Am J Respir Crit Care Med. 2002. PMID: 11956061
Prednisone increases PGH-synthase 2 in atopic humans in vivo.
Dworski RT, Funk CD, Oates JA, Sheller JR. Dworski RT, et al. Among authors: sheller jr. Am J Respir Crit Care Med. 1997 Jan;155(1):351-7. doi: 10.1164/ajrccm.155.1.9001335. Am J Respir Crit Care Med. 1997. PMID: 9001335
Cyclooxygenase inhibition increases interleukin 5 and interleukin 13 production and airway hyperresponsiveness in allergic mice.
Peebles RS Jr, Dworski R, Collins RD, Jarzecka K, Mitchell DB, Graham BS, Sheller JR. Peebles RS Jr, et al. Among authors: sheller jr. Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):676-81. doi: 10.1164/ajrccm.162.2.9911063. Am J Respir Crit Care Med. 2000. PMID: 10934105
Allergen-stimulated release of mediators into sheep bronchoalveolar lavage fluid. Effect of cyclooxygenase inhibition.
Dworski R, Sheller JR, Wickersham NE, Oates JA, Brigham KL, Roberts LJ 2nd, Fitzgerald GA. Dworski R, et al. Among authors: sheller jr. Am Rev Respir Dis. 1989 Jan;139(1):46-51. doi: 10.1164/ajrccm/139.1.46. Am Rev Respir Dis. 1989. PMID: 2492175
Allergen-stimulated release of thromboxane A2 and leukotriene E4 in humans. Effect of indomethacin.
Sladek K, Dworski R, Fitzgerald GA, Buitkus KL, Block FJ, Marney SR Jr, Sheller JR. Sladek K, et al. Among authors: sheller jr. Am Rev Respir Dis. 1990 Jun;141(6):1441-5. doi: 10.1164/ajrccm/141.6.1441. Am Rev Respir Dis. 1990. PMID: 2161626 Clinical Trial.
Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics.
Macfarlane AJ, Dworski R, Sheller JR, Pavord ID, Kay AB, Barnes NC. Macfarlane AJ, et al. Among authors: sheller jr. Am J Respir Crit Care Med. 2000 May;161(5):1553-8. doi: 10.1164/ajrccm.161.5.9906068. Am J Respir Crit Care Med. 2000. PMID: 10806153
Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma.
Brightling CE, Ward R, Woltmann G, Bradding P, Sheller JR, Dworski R, Pavord ID. Brightling CE, et al. Among authors: sheller jr. Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):878-82. doi: 10.1164/ajrccm.162.3.9909064. Am J Respir Crit Care Med. 2000. PMID: 10988099
Prostaglandin E(2) decreases allergen-stimulated release of prostaglandin D(2) in airways of subjects with asthma.
Hartert TV, Dworski RT, Mellen BG, Oates JA, Murray JJ, Sheller JR. Hartert TV, et al. Among authors: sheller jr. Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):637-40. doi: 10.1164/ajrccm.162.2.9904038. Am J Respir Crit Care Med. 2000. PMID: 10934099 Clinical Trial.
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