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Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring.
Mascharak S, desJardins-Park HE, Davitt MF, Griffin M, Borrelli MR, Moore AL, Chen K, Duoto B, Chinta M, Foster DS, Shen AH, Januszyk M, Kwon SH, Wernig G, Wan DC, Lorenz HP, Gurtner GC, Longaker MT. Mascharak S, et al. Among authors: shen ah. Science. 2021 Apr 23;372(6540):eaba2374. doi: 10.1126/science.aba2374. Science. 2021. PMID: 33888614 Free PMC article.
Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis.
Leavitt T, Hu MS, Borrelli MR, Januszyk M, Garcia JT, Ransom RC, Mascharak S, desJardins-Park HE, Litzenburger UM, Walmsley GG, Marshall CD, Moore AL, Duoto B, Adem S, Foster DS, Salhotra A, Shen AH, Griffin M, Shen EZ, Barnes LA, Zielins ER, Maan ZN, Wei Y, Chan CKF, Wan DC, Lorenz HP, Chang HY, Gurtner GC, Longaker MT. Leavitt T, et al. Among authors: shen ez, shen ah. Cell Rep. 2020 Nov 10;33(6):108356. doi: 10.1016/j.celrep.2020.108356. Cell Rep. 2020. PMID: 33176144 Free PMC article.
JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models.
Griffin MF, Borrelli MR, Garcia JT, Januszyk M, King M, Lerbs T, Cui L, Moore AL, Shen AH, Mascharak S, Diaz Deleon NM, Adem S, Taylor WL, desJardins-Park HE, Gastou M, Patel RA, Duoto BA, Sokol J, Wei Y, Foster D, Chen K, Wan DC, Gurtner GC, Lorenz HP, Chang HY, Wernig G, Longaker MT. Griffin MF, et al. Among authors: shen ah. Sci Transl Med. 2021 Sep;13(609):eabb3312. doi: 10.1126/scitranslmed.abb3312. Epub 2021 Sep 1. Sci Transl Med. 2021. PMID: 34516825 Free PMC article.
The antifibrotic adipose-derived stromal cell: Grafted fat enriched with CD74+ adipose-derived stromal cells reduces chronic radiation-induced skin fibrosis.
Borrelli MR, Patel RA, Adem S, Diaz Deleon NM, Shen AH, Sokol J, Yen S, Chang EY, Nazerali R, Nguyen D, Momeni A, Wang KC, Longaker MT, Wan DC. Borrelli MR, et al. Among authors: shen ah. Stem Cells Transl Med. 2020 Nov;9(11):1401-1413. doi: 10.1002/sctm.19-0317. Epub 2020 Jun 20. Stem Cells Transl Med. 2020. PMID: 32563212 Free PMC article.
Decellularized Adipose Matrices Can Alleviate Radiation-Induced Skin Fibrosis.
Adem S, Abbas DB, Lavin CV, Fahy EJ, Griffin M, Diaz Deleon NM, Borrelli MR, Mascharak S, Shen AH, Patel RA, Longaker MT, Nazerali RS, Wan DC. Adem S, et al. Among authors: shen ah. Adv Wound Care (New Rochelle). 2022 Oct;11(10):524-536. doi: 10.1089/wound.2021.0008. Epub 2021 Sep 6. Adv Wound Care (New Rochelle). 2022. PMID: 34346243 Free PMC article.
Profibrotic Signaling Pathways and Surface Markers Are Up-Regulated in Fibroblasts of Human Striae Distensae and in a Mouse Model System.
Borrelli MR, Griffin M, Chen K, Deleon Diaz NM, Adem S, Mascharak S, Shen AH, Ngaage LM, Lewis N, Longaker MT, Gurtner G, Wan DC, Lorenz HP. Borrelli MR, et al. Among authors: shen ah. Plast Reconstr Surg. 2022 Aug 1;150(2):327-338. doi: 10.1097/PRS.0000000000009363. Epub 2022 Jun 6. Plast Reconstr Surg. 2022. PMID: 35666152
47 results