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Page 1
Endocytosis in the axon initial segment maintains neuronal polarity.
Eichel K, Uenaka T, Belapurkar V, Lu R, Cheng S, Pak JS, Taylor CA, Südhof TC, Malenka R, Wernig M, Özkan E, Perrais D, Shen K. Eichel K, et al. Among authors: shen k. Nature. 2022 Sep;609(7925):128-135. doi: 10.1038/s41586-022-05074-5. Epub 2022 Aug 17. Nature. 2022. PMID: 35978188 Free PMC article.
How the AIS maintains polarity between these compartments is not fully understood. Here we find that in Caenorhabditis elegans, mouse, rat and human neurons, dendritically and axonally polarized transmembrane proteins are recognized by endocytic machinery in the AIS, robus …
How the AIS maintains polarity between these compartments is not fully understood. Here we find that in Caenorhabditis elegans, mouse …
25th Annual Computational Neuroscience Meeting: CNS-2016.
Sharpee TO, Destexhe A, Kawato M, Sekulić V, Skinner FK, Wójcik DK, Chintaluri C, Cserpán D, Somogyvári Z, Kim JK, Kilpatrick ZP, Bennett MR, Josić K, Elices I, Arroyo D, Levi R, Rodriguez FB, Varona P, Hwang E, Kim B, Han HB, Kim T, McKenna JT, Brown RE, McCarley RW, Choi JH, Rankin J, Popp PO, Rinzel J, Tabas A, Rupp A, Balaguer-Ballester E, Maturana MI, Grayden DB, Cloherty SL, Kameneva T, Ibbotson MR, Meffin H, Koren V, Lochmann T, Dragoi V, Obermayer K, Psarrou M, Schilstra M, Davey N, Torben-Nielsen B, Steuber V, Ju H, Yu J, Hines ML, Chen L, Yu Y, Kim J, Leahy W, Shlizerman E, Birgiolas J, Gerkin RC, Crook SM, Viriyopase A, Memmesheimer RM, Gielen S, Dabaghian Y, DeVito J, Perotti L, Kim AJ, Fenk LM, Cheng C, Maimon G, Zhao C, Widmer Y, Sprecher S, Senn W, Halnes G, Mäki-Marttunen T, Keller D, Pettersen KH, Andreassen OA, Einevoll GT, Yamada Y, Steyn-Ross ML, Alistair Steyn-Ross D, Mejias JF, Murray JD, Kennedy H, Wang XJ, Kruscha A, Grewe J, Benda J, Lindner B, Badel L, Ohta K, Tsuchimoto Y, Kazama H, Kahng B, Tam ND, Pollonini L, Zouridakis G, Soh J, Kim D, Yoo M, Palmer SE, Culmone V, Bojak I, Ferrario A, Merrison-Hort R, Borisyuk R, Kim CS, Tezuka T, Joo P, Rho YA, Burt… See abstract for full author list ➔ Sharpee TO, et al. Among authors: shen k. BMC Neurosci. 2016 Aug 18;17 Suppl 1(Suppl 1):54. doi: 10.1186/s12868-016-0283-6. BMC Neurosci. 2016. PMID: 27534393 Free PMC article.
Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Ma …
Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, …
Neurite Development and Repair in Worms and Flies.
Richardson CE, Shen K. Richardson CE, et al. Among authors: shen k. Annu Rev Neurosci. 2019 Jul 8;42:209-226. doi: 10.1146/annurev-neuro-070918-050208. Epub 2019 Mar 18. Annu Rev Neurosci. 2019. PMID: 30883262 Review.
How the nervous system is wired has been a central question of neuroscience since the inception of the field, and many of the foundational discoveries and conceptual advances have been made through the study of invertebrate experimental organisms, including Caenorhabditis eleg …
How the nervous system is wired has been a central question of neuroscience since the inception of the field, and many of the foundational d …
GFP Reconstitution Across Synaptic Partners (GRASP) defines cell contacts and synapses in living nervous systems.
Feinberg EH, Vanhoven MK, Bendesky A, Wang G, Fetter RD, Shen K, Bargmann CI. Feinberg EH, et al. Among authors: shen k. Neuron. 2008 Feb 7;57(3):353-63. doi: 10.1016/j.neuron.2007.11.030. Neuron. 2008. PMID: 18255029 Free article.
When one or both GFP fragments are fused to synaptic transmembrane proteins, GFP fluorescence is tightly localized to synapses. GRASP marks known synaptic contacts in C. elegans, correctly identifies changes in mutants with altered synaptic specificity, and can uncover new …
When one or both GFP fragments are fused to synaptic transmembrane proteins, GFP fluorescence is tightly localized to synapses. GRASP marks …
Neuronal polarity in C. elegans.
Ou CY, Shen K. Ou CY, et al. Among authors: shen k. Dev Neurobiol. 2011 Jun;71(6):554-66. doi: 10.1002/dneu.20858. Dev Neurobiol. 2011. PMID: 21557505 Review.
The simplicity and availability of practical genetic tools makes C. elegans as an ideal model to study neuronal polarity in vivo. In recent years, new studies have identified critical polarity molecules that function at different stages of neuronal polarization in C. el …
The simplicity and availability of practical genetic tools makes C. elegans as an ideal model to study neuronal polarity in vivo. In …
Metaxins are core components of mitochondrial transport adaptor complexes.
Zhao Y, Song E, Wang W, Hsieh CH, Wang X, Feng W, Wang X, Shen K. Zhao Y, et al. Among authors: shen k. Nat Commun. 2021 Jan 4;12(1):83. doi: 10.1038/s41467-020-20346-2. Nat Commun. 2021. PMID: 33397950 Free PMC article.
Here we show that metaxins MTX-1 and MTX-2 contribute to mitochondrial transport into both dendrites and axons of C. elegans neurons. MTX1/2 bind to MIRO-1 and kinesin light chain KLC-1, forming a complex to mediate kinesin-1-based movement of mitochondria, in which MTX-1/ …
Here we show that metaxins MTX-1 and MTX-2 contribute to mitochondrial transport into both dendrites and axons of C. elegans neurons. …
A megaprotein brake for aging and insulin-mTOR signaling.
Pandey T, Wang B, Wang C, Zu J, Deng H, Shen K, Dias do Vale G, McDonald JG, Ma DK. Pandey T, et al. Among authors: shen k. bioRxiv. 2023 May 16:2023.02.14.528431. doi: 10.1101/2023.02.14.528431. Preprint. bioRxiv. 2023. PMID: 36824874 Free PMC article.
Here we identify LPD-3 as a megaprotein that orchestrates the tempo of insulin-mTOR signaling during C. elegans aging. We find that an agonist insulin INS-7 is drastically over-produced and shortens lifespan in lpd-3 mutants, a C. elegans model of human Alkuraya-Kuc …
Here we identify LPD-3 as a megaprotein that orchestrates the tempo of insulin-mTOR signaling during C. elegans aging. We find that a …
Microtubule Organization Determines Axonal Transport Dynamics.
Yogev S, Cooper R, Fetter R, Horowitz M, Shen K. Yogev S, et al. Among authors: shen k. Neuron. 2016 Oct 19;92(2):449-460. doi: 10.1016/j.neuron.2016.09.036. Neuron. 2016. PMID: 27764672 Free PMC article.
This method circumvents the need for electron microscopy reconstructions and is compatible with live imaging of cargo transport and MT dynamics. Examination of a C. elegans motor neuron revealed how age, MT-associated proteins, and signaling pathways control MT length, min …
This method circumvents the need for electron microscopy reconstructions and is compatible with live imaging of cargo transport and MT dynam …
Cellular and molecular mechanisms of synaptic specificity.
Yogev S, Shen K. Yogev S, et al. Among authors: shen k. Annu Rev Cell Dev Biol. 2014;30:417-37. doi: 10.1146/annurev-cellbio-100913-012953. Epub 2014 Aug 15. Annu Rev Cell Dev Biol. 2014. PMID: 25150010 Review.
95 results