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Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG.
Gunasekaran K, Pentony M, Shen M, Garrett L, Forte C, Woodward A, Ng SB, Born T, Retter M, Manchulenko K, Sweet H, Foltz IN, Wittekind M, Yan W. Gunasekaran K, et al. Among authors: Shen M. J Biol Chem. 2010 Jun 18;285(25):19637-46. doi: 10.1074/jbc.M110.117382. Epub 2010 Apr 16. J Biol Chem. 2010. PMID: 20400508 Free PMC article.
In vivo crystallization of human IgG in the endoplasmic reticulum of engineered Chinese hamster ovary (CHO) cells.
Hasegawa H, Wendling J, He F, Trilisky E, Stevenson R, Franey H, Kinderman F, Li G, Piedmonte DM, Osslund T, Shen M, Ketchem RR. Hasegawa H, et al. Among authors: Shen M. J Biol Chem. 2011 Jun 3;286(22):19917-31. doi: 10.1074/jbc.M110.204362. Epub 2011 Apr 4. J Biol Chem. 2011. PMID: 21464137 Free PMC article.
A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism.
Liu Z, Leng EC, Gunasekaran K, Pentony M, Shen M, Howard M, Stoops J, Manchulenko K, Razinkov V, Liu H, Fanslow W, Hu Z, Sun N, Hasegawa H, Clark R, Foltz IN, Yan W. Liu Z, et al. Among authors: Shen M. J Biol Chem. 2015 Mar 20;290(12):7535-62. doi: 10.1074/jbc.M114.620260. Epub 2015 Jan 12. J Biol Chem. 2015. PMID: 25583986 Free PMC article.
Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.
Davis MI, Gross S, Shen M, Straley KS, Pragani R, Lea WA, Popovici-Muller J, DeLaBarre B, Artin E, Thorne N, Auld DS, Li Z, Dang L, Boxer MB, Simeonov A. Davis MI, et al. Among authors: Shen M. J Biol Chem. 2014 May 16;289(20):13717-25. doi: 10.1074/jbc.M113.511030. Epub 2014 Mar 25. J Biol Chem. 2014. PMID: 24668804 Free PMC article.
Functional role of death-associated protein 3 (DAP3) in anoikis.
Miyazaki T, Shen M, Fujikura D, Tosa N, Kim HR, Kon S, Uede T, Reed JC. Miyazaki T, et al. Among authors: Shen M. J Biol Chem. 2004 Oct 22;279(43):44667-72. doi: 10.1074/jbc.M408101200. Epub 2004 Aug 9. J Biol Chem. 2004. PMID: 15302871
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