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Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
Cheung KL, Zhang F, Jaganathan A, Sharma R, Zhang Q, Konuma T, Shen T, Lee JY, Ren C, Chen CH, Lu G, Olson MR, Zhang W, Kaplan MH, Littman DR, Walsh MJ, Xiong H, Zeng L, Zhou MM. Cheung KL, et al. Among authors: Shen T. Mol Cell. 2017 Mar 16;65(6):1068-1080.e5. doi: 10.1016/j.molcel.2016.12.022. Epub 2017 Mar 3. Mol Cell. 2017. PMID: 28262505 Free PMC article.
In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-regulate during mouse T helper 17 (Th17) cell differentiation. ...
In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-reg …
BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Cheung K, Lu G, Sharma R, Vincek A, Zhang R, Plotnikov AN, Zhang F, Zhang Q, Ju Y, Hu Y, Zhao L, Han X, Meslamani J, Xu F, Jaganathan A, Shen T, Zhu H, Rusinova E, Zeng L, Zhou J, Yang J, Peng L, Ohlmeyer M, Walsh MJ, Zhang DY, Xiong H, Zhou MM. Cheung K, et al. Among authors: Shen T. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2952-2957. doi: 10.1073/pnas.1615601114. Epub 2017 Mar 6. Proc Natl Acad Sci U S A. 2017. PMID: 28265070 Free PMC article.
T-helper 17 (Th17) cells have important functions in adaptor immunity and have also been implicated in inflammatory disorders. The bromodomain and extraterminal domain (BET) family proteins regulate gene transcription during lineage-specific differentiation of naïve CD4(+) T cells to produce mature T-helper cells. ...
T-helper 17 (Th17) cells have important functions in adaptor immunity and have also been implicated in inflammatory disorders. The br
Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains.
Zhang G, Plotnikov AN, Rusinova E, Shen T, Morohashi K, Joshua J, Zeng L, Mujtaba S, Ohlmeyer M, Zhou MM. Zhang G, et al. Among authors: Shen T. J Med Chem. 2013 Nov 27;56(22):9251-64. doi: 10.1021/jm401334s. Epub 2013 Nov 11. J Med Chem. 2013. PMID: 24144283 Free PMC article.
Association of Nijmegen Breakage Syndrome 1 Genotypes With Bladder Cancer Risk.
Chen M, Chang WS, Shen TC, Gong CL, Lin ML, Wang ZH, Wang YC, Chen CH, Wu HC, Bau DT, Tsai CW. Chen M, et al. Among authors: Shen TC. Anticancer Res. 2020 Apr;40(4):2011-2017. doi: 10.21873/anticanres.14157. Anticancer Res. 2020. PMID: 32234891
Prevalence and causes of vision loss in sub-Saharan Africa in 2015: magnitude, temporal trends and projections.
Naidoo K, Kempen JH, Gichuhi S, Braithwaite T, Casson RJ, Cicinelli MV, Das A, Flaxman SR, Jonas JB, Keeffe JE, Leasher J, Limburg H, Pesudovs K, Resnikoff S, Silvester AJ, Tahhan N, Taylor HR, Wong TY, Bourne RRA; Vision Loss Expert Group of the Global Burden of Disease Study. Naidoo K, et al. Br J Ophthalmol. 2020 Mar 30:bjophthalmol-2019-315217. doi: 10.1136/bjophthalmol-2019-315217. Online ahead of print. Br J Ophthalmol. 2020. PMID: 32229517
Angiotensin-Converting Enzyme Inhibitor Rapidly Ameliorates Depressive-Type Behaviors via Bradykinin-Dependent Activation of Mammalian Target of Rapamycin Complex 1.
Luo H, Wu PF, Cao Y, Jin M, Shen TT, Wang J, Huang JG, Han QQ, He JG, Deng SL, Ni L, Hu ZL, Long LH, Wang F, Chen JG. Luo H, et al. Among authors: Shen TT. Biol Psychiatry. 2020 Feb 18:S0006-3223(20)30094-9. doi: 10.1016/j.biopsych.2020.02.005. Online ahead of print. Biol Psychiatry. 2020. PMID: 32220499
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