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Clozapine directly increases insulin and glucagon secretion from islets: implications for impairment of glucose tolerance.
Smith GC, Zhang ZY, Mulvey T, Petersen N, Lach S, Xiu P, Phillips A, Han W, Wang MW, Shepherd PR. Smith GC, et al. Schizophr Res. 2014 Aug;157(1-3):128-33. doi: 10.1016/j.schres.2014.05.003. Epub 2014 Jun 3. Schizophr Res. 2014. PMID: 24906220
β-catenin is important for the development of an insulin responsive pool of GLUT4 glucose transporters in 3T3-L1 adipocytes.
Dissanayake WC, Sorrenson B, Cognard E, Hughes WE, Shepherd PR. Dissanayake WC, et al. Exp Cell Res. 2018 May 1;366(1):49-54. doi: 10.1016/j.yexcr.2018.03.011. Epub 2018 Mar 11. Exp Cell Res. 2018. PMID: 29540328
Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance.
Hughes VA, Fiatarone MA, Fielding RA, Kahn BB, Ferrara CM, Shepherd P, Fisher EC, Wolfe RR, Elahi D, Evans WJ. Hughes VA, et al. Am J Physiol. 1993 Jun;264(6 Pt 1):E855-62. doi: 10.1152/ajpendo.1993.264.6.E855. Am J Physiol. 1993. PMID: 8333511
The role of phosphoinositide 3-kinase C2alpha in insulin signaling.
Falasca M, Hughes WE, Dominguez V, Sala G, Fostira F, Fang MQ, Cazzolli R, Shepherd PR, James DE, Maffucci T. Falasca M, et al. J Biol Chem. 2007 Sep 21;282(38):28226-36. doi: 10.1074/jbc.M704357200. Epub 2007 Jul 20. J Biol Chem. 2007. PMID: 17644513
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.
Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, Gout I, Downes CP, Lamb RF. Harrington LS, et al. J Cell Biol. 2004 Jul 19;166(2):213-23. doi: 10.1083/jcb.200403069. Epub 2004 Jul 12. J Cell Biol. 2004. PMID: 15249583 Free PMC article.
Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo.
Foukas LC, Beeton CA, Jensen J, Phillips WA, Shepherd PR. Foukas LC, et al. Mol Cell Biol. 2004 Feb;24(3):966-75. doi: 10.1128/mcb.24.3.966-975.2004. Mol Cell Biol. 2004. PMID: 14729945 Free PMC article.
Secrets of insulin and IGF-1 regulation of insulin secretion revealed.
Shepherd PR. Shepherd PR. Biochem J. 2004 Jan 1;377(Pt 1):e1-2. doi: 10.1042/BJ20031747. Biochem J. 2004. PMID: 14672535 Free PMC article.
Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism.
Li L, Grønning LM, Anderson PO, Li S, Edvardsen K, Johnston J, Kioussis D, Shepherd PR, Wang P. Li L, et al. J Biol Chem. 2004 Aug 13;279(33):34107-14. doi: 10.1074/jbc.M312672200. Epub 2004 Apr 27. J Biol Chem. 2004. PMID: 15123678
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