Shepherd TR - Search Results

1

Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ.

Punekar AS, Liljeruhm J, Shepherd TR, Forster AC, Selmer M. Punekar AS, et al. Among authors: shepherd tr. Nucleic Acids Res. 2013 Nov;41(20):9537-48. doi: 10.1093/nar/gkt719. Epub 2013 Aug 13. Nucleic Acids Res. 2013. PMID: 23945937 Free PMC article.

2

Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA.

Punekar AS, Shepherd TR, Liljeruhm J, Forster AC, Selmer M. Punekar AS, et al. Among authors: shepherd tr. Nucleic Acids Res. 2012 Nov 1;40(20):10507-20. doi: 10.1093/nar/gks727. Epub 2012 Aug 25. Nucleic Acids Res. 2012. PMID: 22923526 Free PMC article.

3

De novo design and synthesis of a 30-cistron translation-factor module.

Shepherd TR, Du L, Liljeruhm J, Samudyata, Wang J, Sjödin MOD, Wetterhall M, Yomo T, Forster AC. Shepherd TR, et al. Nucleic Acids Res. 2017 Oct 13;45(18):10895-10905. doi: 10.1093/nar/gkx753. Nucleic Acids Res. 2017. PMID: 28977654 Free PMC article.

4

The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics.

Liu X, Shepherd TR, Murray AM, Xu Z, Fuentes EJ. Liu X, et al. Among authors: shepherd tr. Structure. 2013 Mar 5;21(3):342-54. doi: 10.1016/j.str.2013.01.004. Epub 2013 Feb 7. Structure. 2013. PMID: 23395182 Free PMC article.

5

Distinct ligand specificity of the Tiam1 and Tiam2 PDZ domains.

Shepherd TR, Hard RL, Murray AM, Pei D, Fuentes EJ. Shepherd TR, et al. Biochemistry. 2011 Mar 1;50(8):1296-308. doi: 10.1021/bi1013613. Epub 2011 Feb 4. Biochemistry. 2011. PMID: 21192692 Free PMC article.

6

Structural and thermodynamic analysis of PDZ-ligand interactions.

Shepherd TR, Fuentes EJ. Shepherd TR, et al. Methods Enzymol. 2011;488:81-100. doi: 10.1016/B978-0-12-381268-1.00004-5. Methods Enzymol. 2011. PMID: 21195225 Free PMC article.

7

Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.

Liu X, Speckhard DC, Shepherd TR, Sun YJ, Hengel SR, Yu L, Fowler CA, Gakhar L, Fuentes EJ. Liu X, et al. Among authors: shepherd tr. Structure. 2016 Dec 6;24(12):2053-2066. doi: 10.1016/j.str.2016.08.019. Epub 2016 Oct 27. Structure. 2016. PMID: 27998539 Free PMC article.

8

Conformational Dynamics and Cooperativity Drive the Specificity of a Protein-Ligand Interaction.

Liu X, Golden LC, Lopez JA, Shepherd TR, Yu L, Fuentes EJ. Liu X, et al. Among authors: shepherd tr. Biophys J. 2019 Jun 18;116(12):2314-2330. doi: 10.1016/j.bpj.2019.05.008. Epub 2019 May 11. Biophys J. 2019. PMID: 31146922 Free PMC article.

9

A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress.

Liu Y, Collins C, Kiosses WB, Murray AM, Joshi M, Shepherd TR, Fuentes EJ, Tzima E. Liu Y, et al. Among authors: shepherd tr. J Cell Biol. 2013 Jun 10;201(6):863-73. doi: 10.1083/jcb.201207115. Epub 2013 Jun 3. J Cell Biol. 2013. PMID: 23733346 Free PMC article.

10

The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.

Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ. Shepherd TR, et al. J Mol Biol. 2010 May 21;398(5):730-46. doi: 10.1016/j.jmb.2010.03.047. Epub 2010 Mar 31. J Mol Biol. 2010. PMID: 20361982 Free PMC article.

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