Sheppard D - Search Results

1

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.

Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Henderson NC, et al. Among authors: sheppard d. Nat Med. 2013 Dec;19(12):1617-24. doi: 10.1038/nm.3282. Epub 2013 Nov 10. Nat Med. 2013. PMID: 24216753 Free PMC article.

2

Integrin-mediated activation of transforming growth factor-beta(1) in pulmonary fibrosis.

Sheppard D. Sheppard D. Chest. 2001 Jul;120(1 Suppl):49S-53S. doi: 10.1378/chest.120.1_suppl.s49. Chest. 2001. PMID: 11451914

3

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.

Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ. Kuperman DA, et al. Among authors: sheppard d. Nat Med. 2002 Aug;8(8):885-9. doi: 10.1038/nm734. Epub 2002 Jul 1. Nat Med. 2002. PMID: 12091879

4

Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema.

Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, Glick A, Sheppard D. Morris DG, et al. Among authors: sheppard d. Nature. 2003 Mar 13;422(6928):169-73. doi: 10.1038/nature01413. Nature. 2003. PMID: 12634787

5

Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.

Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D. Travis MA, et al. Among authors: sheppard d. Nature. 2007 Sep 20;449(7160):361-5. doi: 10.1038/nature06110. Epub 2007 Aug 12. Nature. 2007. PMID: 17694047 Free PMC article.

6

Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis.

Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, Adams R, Muro AF, Sheppard D, Makinen T. Bazigou E, et al. Among authors: sheppard d. Dev Cell. 2009 Aug;17(2):175-86. doi: 10.1016/j.devcel.2009.06.017. Dev Cell. 2009. PMID: 19686679 Free PMC article.

7

Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.

Melton AC, Bailey-Bucktrout SL, Travis MA, Fife BT, Bluestone JA, Sheppard D. Melton AC, et al. Among authors: sheppard d. J Clin Invest. 2010 Dec;120(12):4436-44. doi: 10.1172/JCI43786. Epub 2010 Nov 22. J Clin Invest. 2010. PMID: 21099117 Free PMC article.

8

Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force.

Giacomini MM, Travis MA, Kudo M, Sheppard D. Giacomini MM, et al. Among authors: sheppard d. Exp Cell Res. 2012 Apr 1;318(6):716-22. doi: 10.1016/j.yexcr.2012.01.020. Epub 2012 Jan 28. Exp Cell Res. 2012. PMID: 22309779 Free PMC article.

9

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.

Kudo M, Melton AC, Chen C, Engler MB, Huang KE, Ren X, Wang Y, Bernstein X, Li JT, Atabai K, Huang X, Sheppard D. Kudo M, et al. Among authors: sheppard d. Nat Med. 2012 Mar 4;18(4):547-54. doi: 10.1038/nm.2684. Nat Med. 2012. PMID: 22388091 Free PMC article.

10

Integrin-mediated regulation of TGFβ in fibrosis.

Henderson NC, Sheppard D. Henderson NC, et al. Among authors: sheppard d. Biochim Biophys Acta. 2013 Jul;1832(7):891-6. doi: 10.1016/j.bbadis.2012.10.005. Epub 2012 Oct 6. Biochim Biophys Acta. 2013. PMID: 23046811 Free PMC article. Review.

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