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Functional diversity of helper T lymphocytes.
Abbas AK, Murphy KM, Sher A. Abbas AK, et al. Nature. 1996 Oct 31;383(6603):787-93. doi: 10.1038/383787a0. Nature. 1996. PMID: 8893001 Review.
The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. ...
The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a
Mutation of Tec family kinases alters T helper cell differentiation.
Schaeffer EM, Yap GS, Lewis CM, Czar MJ, McVicar DW, Cheever AW, Sher A, Schwartzberg PL. Schaeffer EM, et al. Nat Immunol. 2001 Dec;2(12):1183-8. doi: 10.1038/ni734. Nat Immunol. 2001. PMID: 11702066
Paradoxically, the more severely impaired Rlk-/-Itk-/- mice were able to mount a TH2 response and produced TH2 cytokines in response to this challenge. In addition, Rlk-/-Itk-/- cells showed impaired TCR-induced repression of the TH2-inducing transcription factor GATA-3, s …
Paradoxically, the more severely impaired Rlk-/-Itk-/- mice were able to mount a TH2 response and produced TH2 cytokines in response …
Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus.
Clerici M, Wynn TA, Berzofsky JA, Blatt SP, Hendrix CW, Sher A, Coffman RL, Shearer GM. Clerici M, et al. J Clin Invest. 1994 Feb;93(2):768-75. doi: 10.1172/JCI117031. J Clin Invest. 1994. PMID: 8113410 Free PMC article.
Furthermore, the antigen-specific TH responses of HIV-uninfected PBMC could be reduced with IL-10, a process reversed by anti-IL-10. These results confirm that the early loss of TH function in HIV+ individuals is due at least in part to cytokine-induced immune dysregulatio …
Furthermore, the antigen-specific TH responses of HIV-uninfected PBMC could be reduced with IL-10, a process reversed by anti-IL-10. …
Toxoplasma gondii possesses a superantigen activity that selectively expands murine T cell receptor V beta 5-bearing CD8+ lymphocytes.
Denkers EY, Caspar P, Sher A. Denkers EY, et al. J Exp Med. 1994 Sep 1;180(3):985-94. doi: 10.1084/jem.180.3.985. J Exp Med. 1994. PMID: 8064244 Free PMC article.
Based on several key criteria, the response appeared to be driven by a superantigen present in the parasite. Thus, stimulation of C57BL/6 spleen cells with T. gondii resulted in a preferential threefold expansion of a T cell population expressing the V beta 5 …
Based on several key criteria, the response appeared to be driven by a superantigen present in the parasite. Thus, stimulation of C57 …
Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile.
Jankovic D, Kullberg MC, Noben-Trauth N, Caspar P, Paul WE, Sher A. Jankovic D, et al. J Immunol. 2000 Mar 15;164(6):3047-55. doi: 10.4049/jimmunol.164.6.3047. J Immunol. 2000. PMID: 10706693
In this study, we formally demonstrate by single cell analysis that CD4+ lymphocytes with a classical Th2 phenotype (IL-4+, IL-5+, IFN-gamma-, IL-2-) develop in significant numbers in helminth-infected mice deficient in either IL-4R alpha-chain or Stat6. While an expanded …
In this study, we formally demonstrate by single cell analysis that CD4+ lymphocytes with a classical Th2 phenotype (IL-4+, IL-5+, IF …
Diversity of cytokine synthesis and function of mouse CD4+ T cells.
Mosmann TR, Schumacher JH, Street NF, Budd R, O'Garra A, Fong TA, Bond MW, Moore KW, Sher A, Fiorentino DF. Mosmann TR, et al. Immunol Rev. 1991 Oct;123:209-29. doi: 10.1111/j.1600-065x.1991.tb00612.x. Immunol Rev. 1991. PMID: 1684780 Review. No abstract available.
A role for CD4+ NK1.1+ T lymphocytes as major histocompatibility complex class II independent helper cells in the generation of CD8+ effector function against intracellular infection.
Denkers EY, Scharton-Kersten T, Barbieri S, Caspar P, Sher A. Denkers EY, et al. J Exp Med. 1996 Jul 1;184(1):131-9. doi: 10.1084/jem.184.1.131. J Exp Med. 1996. PMID: 8691126 Free PMC article.
Major histocompatibility complex (MHC) class II (A beta) knockout mice were vaccinated with ts-4, an attenuated mutant strain of Toxoplasma gondii, which in normal animals induces strong T cell immunity mediated by interferon gamma (IFN-gamma). ...Moreover, the data argue …
Major histocompatibility complex (MHC) class II (A beta) knockout mice were vaccinated with ts-4, an attenuated mutant strain of Toxo …
An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection.
Wynn TA, Cheever AW, Jankovic D, Poindexter RW, Caspar P, Lewis FA, Sher A. Wynn TA, et al. Nature. 1995 Aug 17;376(6541):594-6. doi: 10.1038/376594a0. Nature. 1995. PMID: 7637808
These results are an example of a vaccine against parasites which acts by preventing pathology rather than infection. IL-12 is known to favour the priming of TH1 rather than Th2 cells, and the effects on fibrosis are accompanied by replacement of the Th2-dominated pattern …
These results are an example of a vaccine against parasites which acts by preventing pathology rather than infection. IL-12 is known …
Immunization against parasites: bridging the gap between attenuated and non-living vaccines.
Sher A, Gazzinelli R, Hakim F, de la Cruz VF, Stover CK, James SL, Pearce E. Sher A, et al. Behring Inst Mitt. 1991 Feb;(88):244-8. Behring Inst Mitt. 1991. PMID: 2049045 Review.
We hypothesize that cytokine manipulation may offer a useful strategy for improving the action of existing nonliving vaccines. ...Our preliminary results in the construction and testing of a recombinant BCG vector incorporating schistosome paramyosin are described.. …
We hypothesize that cytokine manipulation may offer a useful strategy for improving the action of existing nonliving vaccines. ...Our …
Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni.
Pearce EJ, Caspar P, Grzych JM, Lewis FA, Sher A. Pearce EJ, et al. J Exp Med. 1991 Jan 1;173(1):159-66. doi: 10.1084/jem.173.1.159. J Exp Med. 1991. PMID: 1824635 Free PMC article.
In the mouse, infection with Schistosoma mansoni results in an egg-producing infection and associated disease, whereas vaccination with attenuated larval stages produces a substantial and specific immunity in the absence of egg-induced pathology. ...Moreover, the injection …
In the mouse, infection with Schistosoma mansoni results in an egg-producing infection and associated disease, whereas vaccination with atte …
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