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Could the Anti-Chaperone VER155008 Replace Temozolomide for Glioma Treatment.
Shervington L, Patil H, Shervington A. Shervington L, et al. Among authors: shervington a. J Cancer. 2015 Jul 4;6(8):786-94. doi: 10.7150/jca.12251. eCollection 2015. J Cancer. 2015. PMID: 26185541 Free PMC article.
Can RNAi-mediated hsp90α knockdown in combination with 17-AAG be a therapy for glioma?
Mehta A, Shervington A, Howl J, Jones S, Shervington L. Mehta A, et al. Among authors: shervington a. FEBS Open Bio. 2013 Jun 20;3:271-8. doi: 10.1016/j.fob.2013.06.002. Print 2013. FEBS Open Bio. 2013. PMID: 23905009 Free PMC article.
A novel therapeutic strategy for the treatment of glioma, combining chemical and molecular targeting of hsp90a.
Mehta A, Shervington L, Munje C, Shervington A. Mehta A, et al. Among authors: shervington a. Cancers (Basel). 2011 Dec 8;3(4):4228-44. doi: 10.3390/cancers3044228. Cancers (Basel). 2011. PMID: 24213135 Free PMC article.
Can the lack of HSP90alpha protein in brain normal tissue and cell lines, rationalise it as a possible therapeutic target for gliomas?
Shervington A, Cruickshanks N, Lea R, Roberts G, Dawson T, Shervington L. Shervington A, et al. Cancer Invest. 2008 Nov;26(9):900-4. doi: 10.1080/07357900802087259. Cancer Invest. 2008. PMID: 18798074
Despite studies suggesting a role for HSP90alpha in tumorigenesis, there are no reports as to its expression in normal human brain tissue. ...These findings provide a rationale for targeting HSP90alpha protein as a therapeutic candidate for glioma....
Despite studies suggesting a role for HSP90alpha in tumorigenesis, there are no reports as to its expression in normal human brain ti …
Silencing DNA methyltransferase (DNMT) enhances glioma chemosensitivity.
Shervington A, Patel R. Shervington A, et al. Oligonucleotides. 2008 Dec;18(4):365-74. doi: 10.1089/oli.2008.0128. Oligonucleotides. 2008. PMID: 18928331
Although the results were encouraging, the fact that 5azadC is highly toxic and nonspecific, thus is not favored as a therapeutic molecule. ...Results suggest that either a combination of siRNA 1 or 3 followed by taxol (2-6 muM) after 48 hours or a combinatio …
Although the results were encouraging, the fact that 5azadC is highly toxic and nonspecific, thus is not favored as a therapeutic mol …
The complexity of identifying cancer stem cell biomarkers.
Khan Z, Shervington A, Munje C, Shervington L. Khan Z, et al. Among authors: shervington a. Cancer Invest. 2013 Jul;31(6):404-11. doi: 10.3109/07357907.2013.802800. Epub 2013 Jun 11. Cancer Invest. 2013. PMID: 23758188
Can hsp90alpha-targeted siRNA combined with TMZ be a future therapy for glioma?
Cruickshanks N, Shervington L, Patel R, Munje C, Thakkar D, Shervington A. Cruickshanks N, et al. Among authors: shervington a. Cancer Invest. 2010 Jul;28(6):608-14. doi: 10.3109/07357901003630967. Cancer Invest. 2010. PMID: 20210521
Proteomics: the tool to bridge the gap between the facts and fables of telomerase.
Thakkar D, Shervington A. Thakkar D, et al. Crit Rev Oncog. 2008;14(4):203-15. doi: 10.1615/critrevoncog.v14.i4.10. Crit Rev Oncog. 2008. PMID: 19645682 Review.
Genomic analysis has provided a huge cohort of data that has shed light on the regulation and structure of telomerase and will continue to influence its study profoundly. ...This review highlights significant advances in understanding the regulation of telomerase activity …
Genomic analysis has provided a huge cohort of data that has shed light on the regulation and structure of telomerase and will contin …
Telomerase downregulation in cancer brain stem cell.
Shervington A, Lu C, Patel R, Shervington L. Shervington A, et al. Mol Cell Biochem. 2009 Nov;331(1-2):153-9. doi: 10.1007/s11010-009-0153-y. Epub 2009 May 9. Mol Cell Biochem. 2009. PMID: 19430894
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