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Stereoselective oxidative metabolism of propranolol in the microsomal fraction from rat and human liver. Use of deuterium labeling and pseudoracemic mixtures.

Nelson WL, Shetty HU. Nelson WL, et al. Among authors: shetty hu. Drug Metab Dispos. 1986 Jul-Aug;14(4):506-8. Drug Metab Dispos. 1986. PMID: 2874001 No abstract available.

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Chemical and stereochemical aspects of propranolol metabolism. Diastereomeric 1-(1-hydroxy-2-propylamino)-3-(1-naphthoxy)-2-propanols produced by rat liver microsomal omega-hydroxylation.

Shetty HU, Nelson WL. Shetty HU, et al. J Med Chem. 1986 Oct;29(10):2004-8. doi: 10.1021/jm00160a034. J Med Chem. 1986. PMID: 3761318

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Enantioselective and diastereoselective aspects of the oxidative metabolism of metoprolol.

Murthy SS, Shetty HU, Nelson WL, Jackson PR, Lennard MS. Murthy SS, et al. Among authors: shetty hu. Biochem Pharmacol. 1990 Oct 1;40(7):1637-44. doi: 10.1016/0006-2952(90)90466-x. Biochem Pharmacol. 1990. PMID: 2222517

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Chemical aspects of metoprolol metabolism. Asymmetric synthesis and absolute configuration of the 3-[4-(1-hydroxy-2-methoxyethyl)phenoxy]-1-(isopropylamino)-2-propanols , the diastereomeric benzylic hydroxylation metabolites.

Shetty HU, Nelson WL. Shetty HU, et al. J Med Chem. 1988 Jan;31(1):55-9. doi: 10.1021/jm00396a009. J Med Chem. 1988. PMID: 3336032

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Attempts to use cyanide ion to trap imine intermediates in the microsomal N-dealkylation of propranolol: formation of alpha-aminonitriles as artifacts when using ether for extraction.

Shetty HU, Nelson WL. Shetty HU, et al. J Pharm Sci. 1985 Sep;74(9):968-71. doi: 10.1002/jps.2600740912. J Pharm Sci. 1985. PMID: 4067851

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Synthesis and evaluation of two 18F-labeled 6-iodo-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine derivatives as prospective radioligands for beta-amyloid in Alzheimer's disease.

Cai L, Chin FT, Pike VW, Toyama H, Liow JS, Zoghbi SS, Modell K, Briard E, Shetty HU, Sinclair K, Donohue S, Tipre D, Kung MP, Dagostin C, Widdowson DA, Green M, Gao W, Herman MM, Ichise M, Innis RB. Cai L, et al. Among authors: shetty hu. J Med Chem. 2004 Apr 22;47(9):2208-18. doi: 10.1021/jm030477w. J Med Chem. 2004. PMID: 15084119 Free PMC article.

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Synthesis of deuterium-labeled fluphenazine.

Shetty HU, Hawes EM, Midha KK. Shetty HU, et al. J Pharm Sci. 1984 Jan;73(1):87-90. doi: 10.1002/jps.2600730123. J Pharm Sci. 1984. PMID: 6694091

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Radioimmunoassay for psychotropic drugs. III: Synthesis and properties of haptens for trifluoperazine and fluphenazine.

Hawes EM, Shetty HU, Cooper JK, Rauw G, McKay G, Midha KK. Hawes EM, et al. Among authors: shetty hu. J Pharm Sci. 1984 Feb;73(2):247-50. doi: 10.1002/jps.2600730226. J Pharm Sci. 1984. PMID: 6707894

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Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET.

Briard E, Zoghbi SS, Siméon FG, Imaizumi M, Gourley JP, Shetty HU, Lu S, Fujita M, Innis RB, Pike VW. Briard E, et al. Among authors: shetty hu. J Med Chem. 2009 Feb 12;52(3):688-99. doi: 10.1021/jm8011855. J Med Chem. 2009. PMID: 19119848 Free PMC article.

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Radiodefluorination of 3-fluoro-5-(2-(2-[18F](fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a radioligand for imaging brain metabotropic glutamate subtype-5 receptors with positron emission tomography, occurs by glutathionylation in rat brain.

Shetty HU, Zoghbi SS, Siméon FG, Liow JS, Brown AK, Kannan P, Innis RB, Pike VW. Shetty HU, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):727-35. doi: 10.1124/jpet.108.143347. Epub 2008 Sep 19. J Pharmacol Exp Ther. 2008. PMID: 18806125 Free PMC article.

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