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Cerebrospinal fluid and plasma distribution of myo-inositol and other polyols in Alzheimer disease.
Shetty HU, Holloway HW, Schapiro MB. Shetty HU, et al. Clin Chem. 1996 Feb;42(2):298-302. Clin Chem. 1996. PMID: 8595727
Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridines as radioligands for imaging beta-amyloid plaques in Alzheimer's disease.
Cai L, Liow JS, Zoghbi SS, Cuevas J, Baetas C, Hong J, Shetty HU, Seneca NM, Brown AK, Gladding R, Temme SS, Herman MM, Innis RB, Pike VW. Cai L, et al. Among authors: shetty hu. J Med Chem. 2008 Jan 10;51(1):148-58. doi: 10.1021/jm700970s. Epub 2007 Dec 14. J Med Chem. 2008. PMID: 18078311
Synthesis and evaluation of two 18F-labeled 6-iodo-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine derivatives as prospective radioligands for beta-amyloid in Alzheimer's disease.
Cai L, Chin FT, Pike VW, Toyama H, Liow JS, Zoghbi SS, Modell K, Briard E, Shetty HU, Sinclair K, Donohue S, Tipre D, Kung MP, Dagostin C, Widdowson DA, Green M, Gao W, Herman MM, Ichise M, Innis RB. Cai L, et al. Among authors: shetty hu. J Med Chem. 2004 Apr 22;47(9):2208-18. doi: 10.1021/jm030477w. J Med Chem. 2004. PMID: 15084119 Free PMC article.
Measuring brain uptake and incorporation into brain phosphatidylinositol of plasma myo-[2H6]inositol in unanesthetized rats: an approach to estimate in vivo brain phosphatidylinositol turnover.
Ma K, Deutsch J, Villacreses NE, Rosenberger TA, Rapoport SI, Shetty HU. Ma K, et al. Among authors: shetty hu. Neurochem Res. 2006 Jun;31(6):759-65. doi: 10.1007/s11064-006-9080-4. Epub 2006 Jun 22. Neurochem Res. 2006. PMID: 16791473
Measurement of myo-inositol turnover in phosphatidylinositol: description of a model and mass spectrometric method for cultured cortical neurons.
Chikhale EG, Balbo A, Galdzicki Z, Rapoport SI, Shetty HU. Chikhale EG, et al. Among authors: shetty hu. Biochemistry. 2001 Sep 18;40(37):11114-20. doi: 10.1021/bi010817k. Biochemistry. 2001. PMID: 11551209
Ts65Dn mouse, a Down syndrome model, exhibits elevated myo-inositol in selected brain regions and peripheral tissues.
Shetty HU, Siarey RJ, Galdzicki Z, Stoll J, Rapoport SI. Shetty HU, et al. Neurochem Res. 2000 Apr;25(4):431-5. doi: 10.1023/a:1007592006005. Neurochem Res. 2000. PMID: 10823574
High brain myo-inositol levels in the predementia phase of Alzheimer's disease in adults with Down's syndrome: a 1H MRS study.
Huang W, Alexander GE, Daly EM, Shetty HU, Krasuski JS, Rapoport SI, Schapiro MB. Huang W, et al. Among authors: shetty hu. Am J Psychiatry. 1999 Dec;156(12):1879-86. doi: 10.1176/ajp.156.12.1879. Am J Psychiatry. 1999. PMID: 10588400
Application of stable isotope tracer combined with mass spectrometric detection for studying myo-inositol uptake by cultured neurons from fetal mouse: effect of trisomy 16.
Acevedo LD, Holloway HW, Rapoport SI, Shetty HU. Acevedo LD, et al. Among authors: shetty hu. J Mass Spectrom. 1997 Apr;32(4):395-400. doi: 10.1002/(SICI)1096-9888(199704)32:4<395::AID-JMS487>3.0.CO;2-#. J Mass Spectrom. 1997. PMID: 9130398
Brain accumulation of myo-inositol in the trisomy 16 mouse, an animal model of Down's syndrome.
Shetty HU, Holloway HW, Acevedo LD, Galdzicki Z. Shetty HU, et al. Biochem J. 1996 Jan 1;313 ( Pt 1)(Pt 1):31-3. doi: 10.1042/bj3130031. Biochem J. 1996. PMID: 8546700 Free PMC article.
Polyol profiles in Down syndrome. myo-Inositol, specifically, is elevated in the cerebrospinal fluid.
Shetty HU, Schapiro MB, Holloway HW, Rapoport SI. Shetty HU, et al. J Clin Invest. 1995 Feb;95(2):542-6. doi: 10.1172/JCI117696. J Clin Invest. 1995. PMID: 7860736 Free PMC article. Clinical Trial.
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