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The AKT kinase is activated in multiple myeloma tumor cells.
Hsu J, Shi Y, Krajewski S, Renner S, Fisher M, Reed JC, Franke TF, Lichtenstein A. Hsu J, et al. Among authors: shi y. Blood. 2001 Nov 1;98(9):2853-5. doi: 10.1182/blood.v98.9.2853. Blood. 2001. PMID: 11675360
Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment.
Zeng Z, Shi YX, Tsao T, Qiu Y, Kornblau SM, Baggerly KA, Liu W, Jessen K, Liu Y, Kantarjian H, Rommel C, Fruman DA, Andreeff M, Konopleva M. Zeng Z, et al. Among authors: shi yx. Blood. 2012 Sep 27;120(13):2679-89. doi: 10.1182/blood-2011-11-393934. Epub 2012 Jul 23. Blood. 2012. PMID: 22826565 Free PMC article.
Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells.
Tsao T, Shi Y, Kornblau S, Lu H, Konoplev S, Antony A, Ruvolo V, Qiu YH, Zhang N, Coombes KR, Andreeff M, Kojima K, Konopleva M. Tsao T, et al. Among authors: shi y. Ann Hematol. 2012 Dec;91(12):1861-70. doi: 10.1007/s00277-012-1537-8. Epub 2012 Aug 15. Ann Hematol. 2012. PMID: 22893484 Free PMC article.
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