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247 results

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Page 1
Characteristics of SARS-CoV-2 and COVID-19.
Hu B, Guo H, Zhou P, Shi ZL. Hu B, et al. Among authors: shi zl. Nat Rev Microbiol. 2021 Mar;19(3):141-154. doi: 10.1038/s41579-020-00459-7. Epub 2020 Oct 6. Nat Rev Microbiol. 2021. PMID: 33024307 Free PMC article. Review.
In this Review, we describe the basic virology of SARS-CoV-2, including genomic characteristics and receptor use, highlighting its key difference from previously known coronaviruses. ...We also discuss the potential wildlife hosts and zoonotic origin of this emerging vi …
In this Review, we describe the basic virology of SARS-CoV-2, including genomic characteristics and receptor use, highlighting its ke …
Origin and evolution of pathogenic coronaviruses.
Cui J, Li F, Shi ZL. Cui J, et al. Among authors: shi zl. Nat Rev Microbiol. 2019 Mar;17(3):181-192. doi: 10.1038/s41579-018-0118-9. Nat Rev Microbiol. 2019. PMID: 30531947 Free PMC article. Review.
Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two highly transmissible and pathogenic viruses that emerged in humans at the beginning of the 21st century. Both viruses likely originated in ba …
Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two highly transmis …
Design of customized coronavirus receptors.
Liu P, Huang ML, Guo H, McCallum M, Si JY, Chen YM, Wang CL, Yu X, Shi LL, Xiong Q, Ma CB, Bowen JE, Tong F, Liu C, Sun YH, Yang X, Chen J, Guo M, Li J, Corti D, Veesler D, Shi ZL, Yan H. Liu P, et al. Among authors: shi zl. Nature. 2024 Nov;635(8040):978-986. doi: 10.1038/s41586-024-08121-5. Epub 2024 Oct 30. Nature. 2024. PMID: 39478224
Here we introduce a strategy to engineer functional customized viral receptors (CVRs). The modular design relies on building artificial receptor scaffolds comprising various modules and generating specific virus-binding domains. ...Our study demonstrates the potenti …
Here we introduce a strategy to engineer functional customized viral receptors (CVRs). The modular design relies on building artifici …
A pneumonia outbreak associated with a new coronavirus of probable bat origin.
Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL. Zhou P, et al. Among authors: shi zl. Nature. 2020 Mar;579(7798):270-273. doi: 10.1038/s41586-020-2012-7. Epub 2020 Feb 3. Nature. 2020. PMID: 32015507 Free PMC article.
Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections incl …
Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndr …
Bat-infecting merbecovirus HKU5-CoV lineage 2 can use human ACE2 as a cell entry receptor.
Chen J, Zhang W, Li Y, Liu C, Dong T, Chen H, Wu C, Su J, Li B, Zhang W, Hu B, Jia J, Ma CB, Zhu Y, He X, Li A, Pan K, Lin H, Guo Z, Li C, Zhang L, Yan H, Zhou P, Peng W, Shi ZL. Chen J, et al. Among authors: shi zl. Cell. 2025 Mar 20;188(6):1729-1742.e16. doi: 10.1016/j.cell.2025.01.042. Epub 2025 Feb 18. Cell. 2025. PMID: 39970913
Merbecoviruses comprise four viral species with remarkable genetic diversity: MERS-related coronavirus, Tylonycteris bat coronavirus HKU4, Pipistrellus bat coronavirus HKU5, and Hedgehog coronavirus 1. ...
Merbecoviruses comprise four viral species with remarkable genetic diversity: MERS-related coronavirus, Tylonycteris bat coronavirus …
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors.
Jin Z, Du X, Xu Y, Deng Y, Liu M, Zhao Y, Zhang B, Li X, Zhang L, Peng C, Duan Y, Yu J, Wang L, Yang K, Liu F, Jiang R, Yang X, You T, Liu X, Yang X, Bai F, Liu H, Liu X, Guddat LW, Xu W, Xiao G, Qin C, Shi Z, Jiang H, Rao Z, Yang H. Jin Z, et al. Among authors: shi z. Nature. 2020 Jun;582(7811):289-293. doi: 10.1038/s41586-020-2223-y. Epub 2020 Apr 9. Nature. 2020. PMID: 32272481
A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the aetiological agent responsible for the 2019-2020 viral pneumonia outbreak of coronavirus disease 2019 (COVID-19)(1-4). Currently, there are no targeted therapeutic agents for t …
A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the aetiological agent responsible for the 2019 …
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.
Menachery VD, Yount BL Jr, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS. Menachery VD, et al. Among authors: shi zl. Nat Med. 2015 Dec;21(12):1508-13. doi: 10.1038/nm.3985. Epub 2015 Nov 9. Nat Med. 2015. PMID: 26552008 Free PMC article.
Here we examine the disease potential of a SARS-like virus, SHC014-CoV, which is currently circulating in Chinese horseshoe bat populations. ...On the basis of these findings, we synthetically re-derived an infectious full-length SHC014 recombinant virus and demonst …
Here we examine the disease potential of a SARS-like virus, SHC014-CoV, which is currently circulating in Chinese horseshoe bat popul …
Deep spatial proteomics reveals region-specific features of severe COVID-19-related pulmonary injury.
Mao Y, Chen Y, Li Y, Ma L, Wang X, Wang Q, He A, Liu X, Dong T, Gao W, Xu Y, Liu L, Ren L, Liu Q, Zhou P, Hu B, Zhou Y, Tian R, Shi ZL. Mao Y, et al. Among authors: shi zl. Cell Rep. 2024 Feb 27;43(2):113689. doi: 10.1016/j.celrep.2024.113689. Epub 2024 Jan 18. Cell Rep. 2024. PMID: 38241149 Free article.
Furthermore, we detect increased protein expression associated with viral entry and inflammatory response across multiple regions, suggesting potential therapeutic targets. ...
Furthermore, we detect increased protein expression associated with viral entry and inflammatory response across multiple regions, su …
A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry.
Chen J, Yang X, Si H, Gong Q, Que T, Li J, Li Y, Wu C, Zhang W, Chen Y, Luo Y, Zhu Y, Li B, Luo D, Hu B, Lin H, Jiang R, Jiang T, Li Q, Liu M, Xie S, Su J, Zheng X, Li A, Yao Y, Yang Y, Chen P, Wu A, He M, Lin X, Tong Y, Hu Y, Shi ZL, Zhou P. Chen J, et al. Among authors: shi zl. Cell. 2023 Feb 16;186(4):850-863.e16. doi: 10.1016/j.cell.2023.01.019. Cell. 2023. PMID: 36803605 Free PMC article.
Four nearly identical (99.9%) genome sequences were obtained, and one virus was isolated (MjHKU4r-CoV-1). This virus utilizes human dipeptidyl peptidase-4 (hDPP4) as a receptor and host proteases for cell infection, which is enhanced by a furin cleavage site that is …
Four nearly identical (99.9%) genome sequences were obtained, and one virus was isolated (MjHKU4r-CoV-1). This virus utilizes …
247 results