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Anti-angiogenic function of tocotrienol.
Miyazawa T, Shibata A, Nakagawa K, Tsuzuki T. Miyazawa T, et al. Asia Pac J Clin Nutr. 2008;17 Suppl 1:253-6. Asia Pac J Clin Nutr. 2008. PMID: 18296349
Angiogenesis involves a set of steps, including activation and movement of endothelial cells and tube formation. Control of these steps by drugs or dietary food components is a hopeful approach for the prevention of angiogenic disorders. ...As a result, we fo …
Angiogenesis involves a set of steps, including activation and movement of endothelial cells and tube formation. Control of these ste …
δ-Tocotrienol treatment is more effective against hypoxic tumor cells than normoxic cells: potential implications for cancer therapy.
Shibata A, Nakagawa K, Tsuduki T, Miyazawa T. Shibata A, et al. J Nutr Biochem. 2015 Aug;26(8):832-40. doi: 10.1016/j.jnutbio.2015.02.011. Epub 2015 Apr 14. J Nutr Biochem. 2015. PMID: 25979648
Tocotrienols, unsaturated forms of vitamin E, inhibit the proliferation of a variety of cancer cells and suppress angiogenesis. ...In this study, we demonstrated that δ-tocotrienol (δ-T3) could be used as a novel anticancer agent against human colorectal adenocarcin …
Tocotrienols, unsaturated forms of vitamin E, inhibit the proliferation of a variety of cancer cells and suppress angiogenesis. ...In …
α-Tocopherol suppresses antiangiogenic effect of δ-tocotrienol in human umbilical vein endothelial cells.
Shibata A, Nakagawa K, Tsuduki T, Miyazawa T. Shibata A, et al. J Nutr Biochem. 2015 Apr;26(4):345-50. doi: 10.1016/j.jnutbio.2014.11.010. Epub 2014 Dec 30. J Nutr Biochem. 2015. PMID: 25662730
Recently, tocotrienol (T3), a less well-known form of vitamin E, has gained attention as a potent hypocholesterolemic, anticancer and antiangiogenic agent. However, tocopherol (Toc), a commonly consumed form of vitamin E, has been reported to inhibit T3's eff …
Recently, tocotrienol (T3), a less well-known form of vitamin E, has gained attention as a potent hypocholesterolemic, antican …
Physiological effects and tissue distribution from large doses of tocotrienol in rats.
Shibata A, Nakagawa K, Shirakawa H, Kobayashi T, Kawakami Y, Takashima R, Ohashi A, Sato S, Ohsaki Y, Kimura F, Kimura T, Tsuduki T, Komai M, Miyazawa T. Shibata A, et al. Biosci Biotechnol Biochem. 2012;76(9):1805-8. doi: 10.1271/bbb.120387. Epub 2012 Sep 7. Biosci Biotechnol Biochem. 2012. PMID: 22972347
Supplementation to an AIN93G-based diet of tocotrienol (T3) for 13 weeks administered to Fischer 344/slc rats showed a safety profile with no side effects. ...Under the present experimental conditions, a continuous intake of the T3 concentrate would be safe in the r …
Supplementation to an AIN93G-based diet of tocotrienol (T3) for 13 weeks administered to Fischer 344/slc rats showed a safety profile …
Phosphatidylcholine hydroperoxide promotes VEGF-induced angiogenesis in endothelial cells and rat aorta ring cultures.
Nakagawa K, Shibata A, Saito T, Sookwong P, Kato S, Tsuduki T, Matsubara K, Miyazawa T. Nakagawa K, et al. Biochim Biophys Acta. 2011 Dec;1810(12):1205-11. doi: 10.1016/j.bbagen.2011.08.018. Epub 2011 Sep 10. Biochim Biophys Acta. 2011. PMID: 21925572
BACKGROUND: Phosphatidylcholine hydroperoxide (PCOOH) is a primary oxidation product of PC, and is markedly accumulated in blood plasma and arterial walls in atherosclerotic animals and humans. ...
BACKGROUND: Phosphatidylcholine hydroperoxide (PCOOH) is a primary oxidation product of PC, and is markedly accumulated in blood plas …
gamma-Tocotrienol reduces squalene hydroperoxide-induced inflammatory responses in HaCaT keratinocytes.
Nakagawa K, Shibata A, Maruko T, Sookwong P, Tsuduki T, Kawakami K, Nishida H, Miyazawa T. Nakagawa K, et al. Lipids. 2010 Sep;45(9):833-41. doi: 10.1007/s11745-010-3458-4. Epub 2010 Aug 17. Lipids. 2010. PMID: 20714817
There are however only a few studies on the pathogenic actions (i.e., inflammatory stimuli) of SQ-OOH. Here, we evaluated whether SQ-OOH induced inflammatory responses in immortalized human keratinocytes (HaCaT). ...As a preventive strategy, inflammation could be re …
There are however only a few studies on the pathogenic actions (i.e., inflammatory stimuli) of SQ-OOH. Here, we evaluated whether SQ- …
alpha-Tocopherol attenuates the cytotoxic effect of delta-tocotrienol in human colorectal adenocarcinoma cells.
Shibata A, Nakagawa K, Sookwong P, Tsuduki T, Asai A, Miyazawa T. Shibata A, et al. Biochem Biophys Res Commun. 2010 Jun 25;397(2):214-9. doi: 10.1016/j.bbrc.2010.05.087. Epub 2010 May 20. Biochem Biophys Res Commun. 2010. PMID: 20493172
Furthermore, coadministration of alpha-Toc decreased delta-T3 uptake into DLD-1 cells in a dose-dependent manner. These results indicate that alpha-Toc is not only less cytotoxic to cancer cells, but it also reduces the cytotoxicity of delta-T3 by inhibiting its cellular u …
Furthermore, coadministration of alpha-Toc decreased delta-T3 uptake into DLD-1 cells in a dose-dependent manner. These results indic …
Suppression of gamma-tocotrienol on UVB induced inflammation in HaCaT keratinocytes and HR-1 hairless mice via inflammatory mediators multiple signaling.
Shibata A, Nakagawa K, Kawakami Y, Tsuzuki T, Miyazawa T. Shibata A, et al. J Agric Food Chem. 2010 Jun 9;58(11):7013-20. doi: 10.1021/jf100691g. J Agric Food Chem. 2010. PMID: 20465215
Tocotrienol inhibits secretion of angiogenic factors from human colorectal adenocarcinoma cells by suppressing hypoxia-inducible factor-1alpha.
Shibata A, Nakagawa K, Sookwong P, Tsuduki T, Tomita S, Shirakawa H, Komai M, Miyazawa T. Shibata A, et al. J Nutr. 2008 Nov;138(11):2136-42. doi: 10.3945/jn.108.093237. J Nutr. 2008. PMID: 18936210
Tocotrienol (T3), unsaturated vitamin E, has recently gained considerable attention as a potent antiangiogenic agent minimizing tumor growth, the exact intracellular mechanisms of which remain poorly understood. ...Also, delta-T3 (2 micromol/L) did not affect hypoxia-induc …
Tocotrienol (T3), unsaturated vitamin E, has recently gained considerable attention as a potent antiangiogenic agent minimizing tumor …
Tumor anti-angiogenic effect and mechanism of action of delta-tocotrienol.
Shibata A, Nakagawa K, Sookwong P, Tsuzuki T, Oikawa S, Miyazawa T. Shibata A, et al. Biochem Pharmacol. 2008 Aug 1;76(3):330-9. doi: 10.1016/j.bcp.2008.05.017. Epub 2008 May 28. Biochem Pharmacol. 2008. PMID: 18599020
Our previous cell-culture studies identified a food-derived anti-angiogenic compound, tocotrienol (T3, an unsaturated vitamin E), as a potential angiogenic inhibitor. ...These results suggest that T3 has potential use as a therapeutic dietary supplement for m …
Our previous cell-culture studies identified a food-derived anti-angiogenic compound, tocotrienol (T3, an unsaturated vitamin E), as …
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