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Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via down-regulating angiogenesis.
Osawa T, Muramatsu M, Wang F, Tsuchida R, Kodama T, Minami T, Shibuya M. Osawa T, et al. Among authors: shibuya m. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20725-9. doi: 10.1073/pnas.1108462109. Epub 2011 Dec 5. Proc Natl Acad Sci U S A. 2011. PMID: 22143793 Free PMC article.
Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway.
Lu Y, Xiong Y, Huo Y, Han J, Yang X, Zhang R, Zhu DS, Klein-Hessling S, Li J, Zhang X, Han X, Li Y, Shen B, He Y, Shibuya M, Feng GS, Luo J. Lu Y, et al. Among authors: shibuya m. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2957-62. doi: 10.1073/pnas.1009395108. Epub 2011 Jan 31. Proc Natl Acad Sci U S A. 2011. PMID: 21282639 Free PMC article.
Vascular endothelial growth factor receptor-1 signaling promotes mobilization of macrophage lineage cells from bone marrow and stimulates solid tumor growth.
Muramatsu M, Yamamoto S, Osawa T, Shibuya M. Muramatsu M, et al. Among authors: shibuya m. Cancer Res. 2010 Oct 15;70(20):8211-21. doi: 10.1158/0008-5472.CAN-10-0202. Epub 2010 Oct 5. Cancer Res. 2010. PMID: 20924106
Vascular endothelial growth factor receptor-1 (VEGFR-1) signaling enhances angiogenesis in a surgical sponge model.
Park K, Amano H, Ito Y, Kashiwagi S, Yamazaki Y, Takeda A, Shibuya M, Kitasato H, Majima M. Park K, et al. Among authors: shibuya m. Biomed Pharmacother. 2016 Mar;78:140-149. doi: 10.1016/j.biopha.2016.01.005. Epub 2016 Jan 25. Biomed Pharmacother. 2016. PMID: 26898435
VEGF-VEGFR System as a Target for Suppressing Inflammation and other Diseases.
Shibuya M. Shibuya M. Endocr Metab Immune Disord Drug Targets. 2015;15(2):135-44. doi: 10.2174/1871530315666150316121956. Endocr Metab Immune Disord Drug Targets. 2015. PMID: 25772179 Review.
VEGFR and type-V RTK activation and signaling.
Shibuya M. Shibuya M. Cold Spring Harb Perspect Biol. 2013 Oct 1;5(10):a009092. doi: 10.1101/cshperspect.a009092. Cold Spring Harb Perspect Biol. 2013. PMID: 24086040 Free PMC article. Review.
Structurally, VEGFRs are distantly related to the members of the M-colony stimulating factor receptor/platelet-derived growth factor receptor (CSFR)/(PDGFR) family, which have five immunoglobulin (5 Ig)-like domains. However, signal transduction in VEGFRs significantly dif …
Structurally, VEGFRs are distantly related to the members of the M-colony stimulating factor receptor/platelet-derived growth factor …
Synthesis and biological evaluation of benzamides and benzamidines as selective inhibitors of VEGFR tyrosine kinases.
Nakamura H, Sasaki Y, Uno M, Yoshikawa T, Asano T, Ban HS, Fukazawa H, Shibuya M, Uehara Y. Nakamura H, et al. Among authors: shibuya m. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5127-31. doi: 10.1016/j.bmcl.2006.07.075. Epub 2006 Aug 8. Bioorg Med Chem Lett. 2006. PMID: 16893647
VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice.
Niida S, Kondo T, Hiratsuka S, Hayashi S, Amizuka N, Noda T, Ikeda K, Shibuya M. Niida S, et al. Among authors: shibuya m. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14016-21. doi: 10.1073/pnas.0503544102. Epub 2005 Sep 19. Proc Natl Acad Sci U S A. 2005. PMID: 16172397 Free PMC article.
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