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A single ataxia telangiectasia gene with a product similar to PI-3 kinase.
Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, Tagle DA, Smith S, Uziel T, Sfez S, Ashkenazi M, Pecker I, Frydman M, Harnik R, Patanjali SR, Simmons A, Clines GA, Sartiel A, Gatti RA, Chessa L, Sanal O, Lavin MF, Jaspers NG, Taylor AM, Arlett CF, Miki T, Weissman SM, Lovett M, Collins FS, Shiloh Y. Savitsky K, et al. Science. 1995 Jun 23;268(5218):1749-53. doi: 10.1126/science.7792600. Science. 1995. PMID: 7792600
Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype.
Spring K, Cross S, Li C, Watters D, Ben-Senior L, Waring P, Ahangari F, Lu SL, Chen P, Misko I, Paterson C, Kay G, Smorodinsky NI, Shiloh Y, Lavin MF. Spring K, et al. Cancer Res. 2001 Jun 1;61(11):4561-8. Cancer Res. 2001. PMID: 11389091
ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks.
Li N, Banin S, Ouyang H, Li GC, Courtois G, Shiloh Y, Karin M, Rotman G. Li N, et al. J Biol Chem. 2001 Mar 23;276(12):8898-903. doi: 10.1074/jbc.M009809200. Epub 2000 Dec 12. J Biol Chem. 2001. PMID: 11114307
Fragments of ATM which have dominant-negative or complementing activity.
Morgan SE, Lovly C, Pandita TK, Shiloh Y, Kastan MB. Morgan SE, et al. Mol Cell Biol. 1997 Apr;17(4):2020-9. doi: 10.1128/mcb.17.4.2020. Mol Cell Biol. 1997. PMID: 9121450 Free PMC article.
Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase.
Macaulay VM, Salisbury AJ, Bohula EA, Playford MP, Smorodinsky NI, Shiloh Y. Macaulay VM, et al. Oncogene. 2001 Jul 5;20(30):4029-40. doi: 10.1038/sj.onc.1204565. Oncogene. 2001. PMID: 11494131
Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue.
Rashi-Elkeles S, Elkon R, Weizman N, Linhart C, Amariglio N, Sternberg G, Rechavi G, Barzilai A, Shamir R, Shiloh Y. Rashi-Elkeles S, et al. Oncogene. 2006 Mar 9;25(10):1584-92. doi: 10.1038/sj.onc.1209189. Oncogene. 2006. PMID: 16314843
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