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Inhibition of protein geranylgeranylation specifically interferes with CD40-dependent B cell activation, resulting in a reduced capacity to induce T cell immunity.
Shimabukuro-Vornhagen A, Zoghi S, Liebig TM, Wennhold K, Chemitz J, Draube A, Kochanek M, Blaschke F, Pallasch C, Holtick U, Scheid C, Theurich S, Hallek M, von Bergwelt-Baildon MS. Shimabukuro-Vornhagen A, et al. J Immunol. 2014 Nov 15;193(10):5294-305. doi: 10.4049/jimmunol.1203436. Epub 2014 Oct 13. J Immunol. 2014. PMID: 25311809
Murine model of CD40-activation of B cells.
Liebig TM, Fiedler A, Klein-Gonzalez N, Shimabukuro-Vornhagen A, von Bergwelt-Baildon M. Liebig TM, et al. J Vis Exp. 2010 Mar 5;(37):1734. doi: 10.3791/1734. J Vis Exp. 2010. PMID: 20208476 Free PMC article.
CD40-activated B cells can be generated in high number and purity in cancer patients: analysis of immunogenicity and homing potential.
Kondo E, Gryschok L, Klein-Gonzalez N, Rademacher S, Weihrauch MR, Liebig T, Shimabukuro-Vornhagen A, Kochanek M, Draube A, von Bergwelt-Baildon MS. Kondo E, et al. Clin Exp Immunol. 2009 Feb;155(2):249-56. doi: 10.1111/j.1365-2249.2008.03820.x. Epub 2008 Nov 24. Clin Exp Immunol. 2009. PMID: 19040609 Free PMC article. Review.
123 results