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Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.
Yamazaki H, Nakamura M, Komatsu T, Ohyama K, Hatanaka N, Asahi S, Shimada N, Guengerich FP, Shimada T, Nakajima M, Yokoi T. Yamazaki H, et al. Among authors: shimada t, shimada n. Protein Expr Purif. 2002 Apr;24(3):329-37. doi: 10.1006/prep.2001.1578. Protein Expr Purif. 2002. PMID: 11922748
Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9).
Kiyotani K, Yamazaki H, Fujieda M, Iwano S, Matsumura K, Satarug S, Ujjin P, Shimada T, Guengerich FP, Parkinson A, Honda G, Nakagawa K, Ishizaki T, Kamataki T. Kiyotani K, et al. Among authors: shimada t. Pharmacogenetics. 2003 Nov;13(11):689-95. doi: 10.1097/00008571-200311000-00005. Pharmacogenetics. 2003. PMID: 14583682
Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2.
Zhao B, Guengerich FP, Bellamine A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, Shimada T, Waterman MR. Zhao B, et al. Among authors: shimada t. J Biol Chem. 2005 Mar 25;280(12):11599-607. doi: 10.1074/jbc.M410933200. Epub 2005 Jan 19. J Biol Chem. 2005. PMID: 15659395 Free article.
Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors.
Shimada T, Murayama N, Okada K, Funae Y, Yamazaki H, Guengerich FP. Shimada T, et al. Chem Res Toxicol. 2007 Mar;20(3):489-96. doi: 10.1021/tx600299p. Epub 2007 Feb 10. Chem Res Toxicol. 2007. PMID: 17291012
We have previously shown that several polycyclic aromatic hydrocarbons (PAHs) strongly inhibit their own and other PAH metabolism catalyzed by cytochrome P450 (P450) 1A1, 1A2, and 1B1 [Shimada, T., and Guengerich, F. P. (2006) Chem. Res. Toxicol. 19, 288-294]. ...
We have previously shown that several polycyclic aromatic hydrocarbons (PAHs) strongly inhibit their own and other PAH metabolism catalyzed …
3,228 results