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2,842 results
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Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector.
Nakamura-Takahashi A, Miyake K, Watanabe A, Hirai Y, Iijima O, Miyake N, Adachi K, Nitahara-Kasahara Y, Kinoshita H, Noguchi T, Abe S, Narisawa S, Millán JL, Shimada T, Okada T. Nakamura-Takahashi A, et al. Mol Ther Methods Clin Dev. 2016 Feb 3;3:15059. doi: 10.1038/mtm.2015.59. eCollection 2016. Mol Ther Methods Clin Dev. 2016. PMID: 26904710 Free PMC article.
Prevention of Lethal Murine Hypophosphatasia by Neonatal Ex Vivo Gene Therapy Using Lentivirally Transduced Bone Marrow Cells.
Iijima O, Miyake K, Watanabe A, Miyake N, Igarashi T, Kanokoda C, Nakamura-Takahashi A, Kinoshita H, Noguchi T, Abe S, Narisawa S, Millán JL, Okada T, Shimada T. Iijima O, et al. Hum Gene Ther. 2015 Dec;26(12):801-12. doi: 10.1089/hum.2015.078. Epub 2015 Nov 19. Hum Gene Ther. 2015. PMID: 26467745 Free PMC article.
Gene profiling and bioinformatics analyses reveal time course differential gene expression in surgically resected colorectal tissues.
Yamagishi A, Matsumoto S, Watanabe A, Mizuguchi Y, Hara K, Kan H, Yamada T, Koizumi M, Shinji S, Matsuda A, Sasaki J, Shimada T, Uchida E. Yamagishi A, et al. Oncol Rep. 2014 Apr;31(4):1531-8. doi: 10.3892/or.2014.3053. Epub 2014 Feb 24. Oncol Rep. 2014. PMID: 24573535 Free PMC article.
Perinatal hypophosphatasia caused by uniparental isodisomy.
Watanabe A, Satoh S, Fujita A, Naing BT, Orimo H, Shimada T. Watanabe A, et al. Bone. 2014 Mar;60:93-7. doi: 10.1016/j.bone.2013.12.009. Epub 2013 Dec 12. Bone. 2014. PMID: 24334170
Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers.
Nagahata T, Shimada T, Harada A, Nagai H, Onda M, Yokoyama S, Shiba T, Jin E, Kawanami O, Emi M. Nagahata T, et al. Cancer Sci. 2003 Jun;94(6):515-8. doi: 10.1111/j.1349-7006.2003.tb01475.x. Cancer Sci. 2003. PMID: 12824876
Through several cytoplasmic relay components including DVL-1, the human counterpart of the Drosophila disheveled gene, the signal is transduced to beta-catenin, which then enters the nucleus and forms a complex with T-cell factor (TCF) to activate transcription of Wnt targ …
Through several cytoplasmic relay components including DVL-1, the human counterpart of the Drosophila disheveled gene, the signal is transdu …
Adeno-associated viral vector-mediated expression of endostatin inhibits tumor growth and metastasis in an orthotropic pancreatic cancer model in hamsters.
Noro T, Miyake K, Suzuki-Miyake N, Igarashi T, Uchida E, Misawa T, Yamazaki Y, Shimada T. Noro T, et al. Cancer Res. 2004 Oct 15;64(20):7486-90. doi: 10.1158/0008-5472.CAN-03-1296. Cancer Res. 2004. PMID: 15492274
Prevalence of c.1559delT in ALPL, a common mutation resulting in the perinatal (lethal) form of hypophosphatasia in Japanese and effects of the mutation on heterozygous carriers.
Watanabe A, Karasugi T, Sawai H, Naing BT, Ikegawa S, Orimo H, Shimada T. Watanabe A, et al. J Hum Genet. 2011 Feb;56(2):166-8. doi: 10.1038/jhg.2010.161. Epub 2010 Dec 23. J Hum Genet. 2011. PMID: 21179104
Prenatal genetic diagnosis of severe perinatal (lethal) hypophosphatasia.
Watanabe A, Yamamasu S, Shinagawa T, Suzuki Y, Miyake H, Takeshita T, Orimo H, Shimada T. Watanabe A, et al. J Nippon Med Sch. 2007 Feb;74(1):65-9. doi: 10.1272/jnms.74.65. J Nippon Med Sch. 2007. PMID: 17384481
The infant had been found to have hypophosphatasia on the basis of both clinical and radiologic manifestations and the finding of a homozygous single T nucleotide deletion at 1559 (1559delT) of the TNSALP gene on molecular analysis. ...
The infant had been found to have hypophosphatasia on the basis of both clinical and radiologic manifestations and the finding of a homozygo …
Ex vivo cell-mediated gene therapy for metachromatic leukodystrophy using neurospheres.
Kawabata K, Migita M, Mochizuki H, Miyake K, Igarashi T, Fukunaga Y, Shimada T. Kawabata K, et al. Brain Res. 2006 Jun 13;1094(1):13-23. doi: 10.1016/j.brainres.2006.03.116. Epub 2006 May 26. Brain Res. 2006. PMID: 16729983
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