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5,461 results
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Indoxyl sulfate, a uremic toxin, promotes cell senescence in aorta of hypertensive rats.
Adijiang A, Higuchi Y, Nishijima F, Shimizu H, Niwa T. Adijiang A, et al. Among authors: shimizu h. Biochem Biophys Res Commun. 2010 Sep 3;399(4):637-41. doi: 10.1016/j.bbrc.2010.07.130. Epub 2010 Aug 4. Biochem Biophys Res Commun. 2010. PMID: 20691162
Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
Kurata K, Kawahara H, Nishimura K, Jisaka M, Yokota K, Shimizu H. Kurata K, et al. Among authors: shimizu h. Biochem Biophys Res Commun. 2019 Mar 19;510(4):649-655. doi: 10.1016/j.bbrc.2019.01.122. Epub 2019 Feb 8. Biochem Biophys Res Commun. 2019. PMID: 30739789
The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha.
Danno H, Ishii KA, Nakagawa Y, Mikami M, Yamamoto T, Yabe S, Furusawa M, Kumadaki S, Watanabe K, Shimizu H, Matsuzaka T, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Yamada N, Shimano H. Danno H, et al. Among authors: shimizu h. Biochem Biophys Res Commun. 2010 Jan 8;391(2):1222-7. doi: 10.1016/j.bbrc.2009.12.046. Epub 2009 Dec 16. Biochem Biophys Res Commun. 2010. PMID: 20006574
NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells.
Shimizu H, Bolati D, Adijiang A, Muteliefu G, Enomoto A, Nishijima F, Dateki M, Niwa T. Shimizu H, et al. Am J Physiol Cell Physiol. 2011 Nov;301(5):C1201-12. doi: 10.1152/ajpcell.00471.2010. Epub 2011 Aug 10. Am J Physiol Cell Physiol. 2011. PMID: 21832251
Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate.
Shimizu H, Bolati D, Adijiang A, Enomoto A, Nishijima F, Dateki M, Niwa T. Shimizu H, et al. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1110-7. doi: 10.1152/ajpcell.00217.2010. Epub 2010 Aug 18. Am J Physiol Cell Physiol. 2010. PMID: 20720180
Indoxyl sulfate upregulates expression of ICAM-1 and MCP-1 by oxidative stress-induced NF-kappaB activation.
Tumur Z, Shimizu H, Enomoto A, Miyazaki H, Niwa T. Tumur Z, et al. Among authors: shimizu h. Am J Nephrol. 2010;31(5):435-41. doi: 10.1159/000299798. Epub 2010 Apr 14. Am J Nephrol. 2010. PMID: 20389059
ROS and PDGF-beta [corrected] receptors are critically involved in indoxyl sulfate actions that promote vascular smooth muscle cell proliferation and migration.
Shimizu H, Hirose Y, Nishijima F, Tsubakihara Y, Miyazaki H. Shimizu H, et al. Am J Physiol Cell Physiol. 2009 Aug;297(2):C389-96. doi: 10.1152/ajpcell.00206.2009. Epub 2009 Jun 3. Am J Physiol Cell Physiol. 2009. PMID: 19494236
Tyrosine phosphatase epsilonM stimulates migration and survival of porcine aortic endothelial cells by activating c-Src.
Nakagawa Y, Yamada N, Shimizu H, Shiota M, Tamura M, Kim-Mitsuyama S, Miyazaki H. Nakagawa Y, et al. Among authors: shimizu h. Biochem Biophys Res Commun. 2004 Dec 3;325(1):314-9. doi: 10.1016/j.bbrc.2004.10.029. Biochem Biophys Res Commun. 2004. PMID: 15522235
Indoxyl sulfate upregulates prorenin expression via nuclear factor-κB p65, signal transducer and activator of transcription 3, and reactive oxygen species in proximal tubular cells.
Saito S, Yisireyili M, Shimizu H, Ng HY, Niwa T. Saito S, et al. Among authors: shimizu h. J Ren Nutr. 2015 Mar;25(2):145-8. doi: 10.1053/j.jrn.2014.10.008. Epub 2014 Dec 31. J Ren Nutr. 2015. PMID: 25556305
Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of TGF-β1 and α-smooth muscle actin in proximal tubular cells.
Saito S, Shimizu H, Yisireyili M, Nishijima F, Enomoto A, Niwa T. Saito S, et al. Among authors: shimizu h. Endocrinology. 2014 May;155(5):1899-907. doi: 10.1210/en.2013-1937. Epub 2014 Mar 6. Endocrinology. 2014. PMID: 24601883
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