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Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N(G)-nitro-L-arginine methyl ester-induced hypertensive rat aorta: vasoprotective effects beyond the blood pressure-lowering effects of amlodipine and manidipine.
Toba H, Nakagawa Y, Miki S, Shimizu T, Yoshimura A, Inoue R, Asayama J, Kobara M, Nakata T. Toba H, et al. Among authors: shimizu t. Hypertens Res. 2005 Aug;28(8):689-700. doi: 10.1291/hypres.28.689. Hypertens Res. 2005. PMID: 16392774
The direct antioxidative and anti-inflammatory effects of peroxisome proliferator-activated receptors ligands are associated with the inhibition of angiotensin converting enzyme expression in streptozotocin-induced diabetic rat aorta.
Toba H, Miki S, Shimizu T, Yoshimura A, Inoue R, Sawai N, Tsukamoto R, Murakami M, Morita Y, Nakayama Y, Kobara M, Nakata T. Toba H, et al. Among authors: shimizu t. Eur J Pharmacol. 2006 Nov 7;549(1-3):124-32. doi: 10.1016/j.ejphar.2006.08.036. Epub 2006 Aug 30. Eur J Pharmacol. 2006. PMID: 16979161
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