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Suppression of the acute upregulation of phosphorylated-extracellular regulated kinase in ventral tegmental area by a μ-opioid receptor agonist is related to resistance to rewarding effects in a mouse model of bone cancer.
Nakamura A, Ono H, Ando A, Hinata M, Niidome K, Omachi S, Sakaguchi G, Shinohara S. Nakamura A, et al. Among authors: shinohara s. J Pharmacol Sci. 2017 Jan;133(1):9-17. doi: 10.1016/j.jphs.2016.11.004. Epub 2016 Dec 8. J Pharmacol Sci. 2017. PMID: 28034513 Free article.
Ibudilast produces anti-allodynic effects at the persistent phase of peripheral or central neuropathic pain in rats: Different inhibitory mechanism on spinal microglia from minocycline and propentofylline.
Fujita M, Tamano R, Yoneda S, Omachi S, Yogo E, Rokushima M, Shinohara S, Sakaguchi G, Hasegawa M, Asaki T. Fujita M, et al. Among authors: shinohara s. Eur J Pharmacol. 2018 Aug 15;833:263-274. doi: 10.1016/j.ejphar.2018.06.009. Epub 2018 Jun 7. Eur J Pharmacol. 2018. PMID: 29886243
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: orally bioavailable compounds.
Kai H, Morioka Y, Tomida M, Takahashi T, Hattori M, Hanasaki K, Koike K, Chiba H, Shinohara S, Kanemasa T, Iwamoto Y, Takahashi K, Yamaguchi Y, Baba T, Yoshikawa T, Takenaka H. Kai H, et al. Among authors: shinohara s. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3925-9. doi: 10.1016/j.bmcl.2007.04.099. Epub 2007 May 3. Bioorg Med Chem Lett. 2007. PMID: 17531479
Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists.
Kai H, Horiguchi T, Kameyma T, Onodera N, Itoh N, Fujii Y, Ichihashi Y, Hirai K, Shintani T, Nakamura K, Minami K, Kasai E, Yoneda S, Murakami Y, Ogawa H, Sekimoto R, Shinohara S, Yoshida O, Kurose N. Kai H, et al. Among authors: shinohara s. Bioorg Med Chem Lett. 2021 Nov 15;52:128384. doi: 10.1016/j.bmcl.2021.128384. Epub 2021 Sep 26. Bioorg Med Chem Lett. 2021. PMID: 34587541 Free article.
640 results