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Telomeres and telomerases.
Shippen DE. Shippen DE. Curr Opin Genet Dev. 1993 Oct;3(5):759-63. doi: 10.1016/s0959-437x(05)80095-4. Curr Opin Genet Dev. 1993. PMID: 8274859 Review.
Processing of nontelomeric 3' ends by telomerase: default template alignment and endonucleolytic cleavage.
Melek M, Greene EC, Shippen DE. Melek M, et al. Mol Cell Biol. 1996 Jul;16(7):3437-45. doi: 10.1128/mcb.16.7.3437. Mol Cell Biol. 1996. PMID: 8668159 Free PMC article.
Telomerase is a specialized reverse transcriptase that maintains telomeres at chromosome ends by extending preexisting tracts of telomeric DNA and forming telomeres de novo on broken chromosomes. ...These observations suggest a mechanism for the precision of developmentall …
Telomerase is a specialized reverse transcriptase that maintains telomeres at chromosome ends by extending preexisting tracts of telomeric D …
Characterization and developmental patterns of telomerase expression in plants.
Fitzgerald MS, McKnight TD, Shippen DE. Fitzgerald MS, et al. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14422-7. doi: 10.1073/pnas.93.25.14422. Proc Natl Acad Sci U S A. 1996. PMID: 8962067 Free PMC article.
Chromosome healing: spontaneous and programmed de novo telomere formation by telomerase.
Melek M, Shippen DE. Melek M, et al. Bioessays. 1996 Apr;18(4):301-8. doi: 10.1002/bies.950180408. Bioessays. 1996. PMID: 8967898 Review.
In this article we discuss the consequences of telomere loss and the possible mechanisms that the enzyme telomerase employs to form telomeres de novo on broken chromosome ends....
In this article we discuss the consequences of telomere loss and the possible mechanisms that the enzyme telomerase employs to form telomere …
Developmentally regulated initiation of DNA synthesis by telomerase: evidence for factor-assisted de novo telomere formation.
Bednenko J, Melek M, Greene EC, Shippen DE. Bednenko J, et al. EMBO J. 1997 May 1;16(9):2507-18. doi: 10.1093/emboj/16.9.2507. EMBO J. 1997. PMID: 9171363 Free PMC article.
Telomerase serves a dual role at telomeres, maintaining tracts of telomere repeats and forming telomeres de novo on broken chromosomes in a process called chromosome healing. ...Vegetatively growing cells maintain pre-existing telomeres, while cells undergoing macronuclear …
Telomerase serves a dual role at telomeres, maintaining tracts of telomere repeats and forming telomeres de novo on broken chromosome …
Plant telomeres and telomerases. A review.
McKnight TD, Fitzgerald MS, Shippen DE. McKnight TD, et al. Biochemistry (Mosc). 1997 Nov;62(11):1224-31. Biochemistry (Mosc). 1997. PMID: 9467846 Review.
Reiterative dG addition by Euplotes crassus telomerase during extension of non-telomeric DNA.
Bednenko J, Melek M, Shippen DE. Bednenko J, et al. Nucleic Acids Res. 1998 Sep 1;26(17):3998-4004. doi: 10.1093/nar/26.17.3998. Nucleic Acids Res. 1998. PMID: 9705511 Free PMC article.
We postulate that indiscriminate dG addition by telomerase occurs by reiterative copying of C residues in the telomerase RNA templating domain and reflects lateral instability of the primer-template interaction during de novo telomere formation....
We postulate that indiscriminate dG addition by telomerase occurs by reiterative copying of C residues in the telomerase RNA templating doma …
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