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Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH.
Itoh M, Tamura A, Kanai S, Tanaka M, Kanamori Y, Shirakawa I, Ito A, Oka Y, Hidaka I, Takami T, Honda Y, Maeda M, Saito Y, Murata Y, Matozaki T, Nakajima A, Kataoka Y, Ogi T, Ogawa Y, Suganami T. Itoh M, et al. Among authors: shirakawa i. J Exp Med. 2023 Nov 6;220(11):e20220681. doi: 10.1084/jem.20220681. Epub 2023 Sep 19. J Exp Med. 2023. PMID: 37725372 Free PMC article.
Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity.
Kobayashi A, Ito A, Shirakawa I, Tamura A, Tomono S, Shindou H, Hedde PN, Tanaka M, Tsuboi N, Ishimoto T, Akashi-Takamura S, Maruyama S, Suganami T. Kobayashi A, et al. Among authors: shirakawa i. Front Immunol. 2021 Jun 15;12:650856. doi: 10.3389/fimmu.2021.650856. eCollection 2021. Front Immunol. 2021. PMID: 34211460 Free PMC article.
Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects.
Kawakubo M, Tanaka M, Ochi K, Watanabe A, Saka-Tanaka M, Kanamori Y, Yoshioka N, Yamashita S, Goto M, Itoh M, Shirakawa I, Kanai S, Suzuki H, Sawada M, Ito A, Ishigami M, Fujishiro M, Arima H, Ogawa Y, Suganami T. Kawakubo M, et al. Among authors: shirakawa i. Sci Rep. 2020 Jan 22;10(1):983. doi: 10.1038/s41598-020-57935-6. Sci Rep. 2020. PMID: 31969650 Free PMC article.
Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis.
Asakawa M, Itoh M, Suganami T, Sakai T, Kanai S, Shirakawa I, Yuan X, Hatayama T, Shimada S, Akiyama Y, Fujiu K, Inagaki Y, Manabe I, Yamaoka S, Yamada T, Tanaka S, Ogawa Y. Asakawa M, et al. Among authors: shirakawa i. Sci Rep. 2019 Dec 20;9(1):19601. doi: 10.1038/s41598-019-56039-0. Sci Rep. 2019. PMID: 31862949 Free PMC article.
CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis.
Itoh M, Suganami T, Kato H, Kanai S, Shirakawa I, Sakai T, Goto T, Asakawa M, Hidaka I, Sakugawa H, Ohnishi K, Komohara Y, Asano K, Sakaida I, Tanaka M, Ogawa Y. Itoh M, et al. Among authors: shirakawa i. JCI Insight. 2017 Nov 16;2(22):e92902. doi: 10.1172/jci.insight.92902. eCollection 2017 Nov 16. JCI Insight. 2017. PMID: 29202448 Free PMC article.
Synthetic "smart gel" provides glucose-responsive insulin delivery in diabetic mice.
Matsumoto A, Tanaka M, Matsumoto H, Ochi K, Moro-Oka Y, Kuwata H, Yamada H, Shirakawa I, Miyazawa T, Ishii H, Kataoka K, Ogawa Y, Miyahara Y, Suganami T. Matsumoto A, et al. Among authors: shirakawa i. Sci Adv. 2017 Nov 22;3(11):eaaq0723. doi: 10.1126/sciadv.aaq0723. eCollection 2017 Nov. Sci Adv. 2017. PMID: 29202033 Free PMC article.
Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis.
Tanaka M, Ikeda K, Suganami T, Komiya C, Ochi K, Shirakawa I, Hamaguchi M, Nishimura S, Manabe I, Matsuda T, Kimura K, Inoue H, Inagaki Y, Aoe S, Yamasaki S, Ogawa Y. Tanaka M, et al. Among authors: shirakawa i. Nat Commun. 2014 Sep 19;5:4982. doi: 10.1038/ncomms5982. Nat Commun. 2014. PMID: 25236782 Free article.
49 results