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CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx.
Shiroo M, Goff L, Biffen M, Shivnan E, Alexander D. Shiroo M, et al. EMBO J. 1992 Dec;11(13):4887-97. EMBO J. 1992. PMID: 1464315 Free PMC article.
Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver.
Kracht M, Truong O, Totty NF, Shiroo M, Saklatvala J. Kracht M, et al. Among authors: shiroo m. J Exp Med. 1994 Dec 1;180(6):2017-25. doi: 10.1084/jem.180.6.2017. J Exp Med. 1994. PMID: 7964479 Free PMC article.
The chemotactic factor N-formylmethionyl-leucyl-phenylalanine activates microtubule-associated protein 2 (MAP) kinase and a MAP kinase kinase in polymorphonuclear leucocytes.
Thompson HL, Shiroo M, Saklatvala J. Thompson HL, et al. Among authors: shiroo m. Biochem J. 1993 Mar 1;290 ( Pt 2)(Pt 2):483-8. doi: 10.1042/bj2900483. Biochem J. 1993. PMID: 8383965 Free PMC article.
Localization and function of tyrosine-phosphorylated protein in pig oocytes.
Miyano T, Moor RM, Wooding FB, Shiroo M. Miyano T, et al. Among authors: shiroo m. Mol Reprod Dev. 1996 Jul;44(3):408-16. doi: 10.1002/(SICI)1098-2795(199607)44:3<408::AID-MRD14>3.0.CO;2-W. Mol Reprod Dev. 1996. PMID: 8858610
G-proteins are not directly involved in the CD3-antigen-mediated production of inositol phosphates in HPB-ALL T-leukaemia cells expressing phospholipase C isoforms gamma 1 and beta 3.
Biffen M, Shiroo M, Alexander DR. Biffen M, et al. Among authors: shiroo m. Biochem J. 1993 Jan 15;289 ( Pt 2)(Pt 2):387-94. doi: 10.1042/bj2890387. Biochem J. 1993. PMID: 8424784 Free PMC article.
Selective coupling of the T cell antigen receptor to phosphoinositide-derived diacylglycerol production in HPB-ALL T cells correlates with CD45-regulated p59fyn activity.
Biffen M, Shiroo M, Alexander DR. Biffen M, et al. Among authors: shiroo m. Eur J Immunol. 1993 Nov;23(11):2980-7. doi: 10.1002/eji.1830231138. Eur J Immunol. 1993. PMID: 8223875
Interleukin-1 activates a novel protein kinase that phosphorylates the epidermal-growth-factor receptor peptide T669.
Kracht M, Shiroo M, Marshall CJ, Hsuan JJ, Saklatvala J. Kracht M, et al. Among authors: shiroo m. Biochem J. 1994 Sep 15;302 ( Pt 3)(Pt 3):897-905. doi: 10.1042/bj3020897. Biochem J. 1994. PMID: 7945218 Free PMC article.
Does co-aggregation of the CD45 and CD3 antigens inhibit T cell antigen receptor complex-mediated activation of phospholipase C and protein kinase C?
Shivnan E, Biffen M, Shiroo M, Pratt E, Glennie M, Alexander D. Shivnan E, et al. Among authors: shiroo m. Eur J Immunol. 1992 Apr;22(4):1055-62. doi: 10.1002/eji.1830220427. Eur J Immunol. 1992. PMID: 1532359
The role of CD45 in T-cell activation--resolving the paradoxes?
Alexander D, Shiroo M, Robinson A, Biffen M, Shivnan E. Alexander D, et al. Among authors: shiroo m. Immunol Today. 1992 Dec;13(12):477-81. doi: 10.1016/0167-5699(92)90021-X. Immunol Today. 1992. PMID: 1463579 Review.
Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1.
Matsushima K, Shiroo M, Kung HF, Copeland TD. Matsushima K, et al. Among authors: shiroo m. Biochemistry. 1988 May 17;27(10):3765-70. doi: 10.1021/bi00410a037. Biochemistry. 1988. PMID: 3261603
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