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PIKfyve: Partners, significance, debates and paradoxes.
Shisheva A. Shisheva A. Cell Biol Int. 2008 Jun;32(6):591-604. doi: 10.1016/j.cellbi.2008.01.006. Epub 2008 Jan 25. Cell Biol Int. 2008. PMID: 18304842 Free PMC article. Review.
Molecular functions of PIKfyve are elusive but recent advances are consistent with a key role in the course of endosomal transport. PIKfyve dysfunction induces endosome enlargement and profound cytoplasmic vacuolation, likely as a result of impaired normal endosome …
Molecular functions of PIKfyve are elusive but recent advances are consistent with a key role in the course of endosomal transport. P …
The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice.
Ikonomov OC, Sbrissa D, Delvecchio K, Xie Y, Jin JP, Rappolee D, Shisheva A. Ikonomov OC, et al. J Biol Chem. 2011 Apr 15;286(15):13404-13. doi: 10.1074/jbc.M111.222364. Epub 2011 Feb 24. J Biol Chem. 2011. PMID: 21349843 Free PMC article.
Acquisition of unprecedented phosphatidylinositol 3,5-bisphosphate rise in hyperosmotically stressed 3T3-L1 adipocytes, mediated by ArPIKfyve-PIKfyve pathway.
Sbrissa D, Shisheva A. Sbrissa D, et al. J Biol Chem. 2005 Mar 4;280(9):7883-9. doi: 10.1074/jbc.M412729200. Epub 2004 Nov 16. J Biol Chem. 2005. PMID: 15546865
However, acute insulin action did not result in a measurable PtdIns 3,5-P(2) rise, indicating the PtdIns 3,5-P(2) pathway is a specific hyperosmotically activated signaling cascade selectively operating in differentiated 3T3-L1 adipocytes. ...Together these results …
However, acute insulin action did not result in a measurable PtdIns 3,5-P(2) rise, indicating the PtdIns 3,5-P(2) pathway is a
Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency.
Compton LM, Ikonomov OC, Sbrissa D, Garg P, Shisheva A. Compton LM, et al. Among authors: shisheva a. Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C366-77. doi: 10.1152/ajpcell.00104.2016. Epub 2016 Jun 22. Am J Physiol Cell Physiol. 2016. PMID: 27335171 Free PMC article.
Unexpected severe consequences of Pikfyve deletion by aP2- or Aq-promoter-driven Cre expression for glucose homeostasis and mammary gland development.
Ikonomov OC, Sbrissa D, Delvecchio K, Rillema JA, Shisheva A. Ikonomov OC, et al. Among authors: shisheva a. Physiol Rep. 2016 Jun;4(11):e12812. doi: 10.14814/phy2.12812. Physiol Rep. 2016. PMID: 27273882 Free PMC article.
Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells.
Venkatareddy M, Verma R, Kalinowski A, Patel SR, Shisheva A, Garg P. Venkatareddy M, et al. Among authors: shisheva a. J Am Soc Nephrol. 2016 Sep;27(9):2702-19. doi: 10.1681/ASN.2015050555. Epub 2016 Jan 29. J Am Soc Nephrol. 2016. PMID: 26825532 Free PMC article.
The Protein Complex of Neurodegeneration-related Phosphoinositide Phosphatase Sac3 and ArPIKfyve Binds the Lewy Body-associated Synphilin-1, Preventing Its Aggregation.
Ikonomov OC, Sbrissa D, Compton LM, Kumar R, Tisdale EJ, Chen X, Shisheva A. Ikonomov OC, et al. Among authors: shisheva a. J Biol Chem. 2015 Nov 20;290(47):28515-29. doi: 10.1074/jbc.M115.669929. Epub 2015 Sep 24. J Biol Chem. 2015. PMID: 26405034 Free PMC article.
Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis.
Ikonomov OC, Sbrissa D, Venkatareddy M, Tisdale E, Garg P, Shisheva A. Ikonomov OC, et al. Biochim Biophys Acta. 2015 May;1853(5):1240-50. doi: 10.1016/j.bbamcr.2015.01.008. Epub 2015 Jan 22. Biochim Biophys Acta. 2015. PMID: 25619930 Free PMC article.
A hallmark of PIKfyve deficiency is formation of multiple translucent cytoplasmic vacuoles seen by light microscopy in cells cultured in complete media. ...We further revealed a plausible physiologically-relevant Vps34-independent PtdIns3P supply for PIKfyve, operat
A hallmark of PIKfyve deficiency is formation of multiple translucent cytoplasmic vacuoles seen by light microscopy in cells cultured
The PIKfyve-ArPIKfyve-Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines.
Ikonomov OC, Filios C, Sbrissa D, Chen X, Shisheva A. Ikonomov OC, et al. Biochem Biophys Res Commun. 2013 Oct 18;440(2):342-7. doi: 10.1016/j.bbrc.2013.09.080. Epub 2013 Sep 23. Biochem Biophys Res Commun. 2013. PMID: 24070605 Free PMC article.
The phosphoinositide 5-kinase PIKfyve and 5-phosphatase Sac3 are scaffolded by ArPIKfyve in the PIKfyve-ArPIKfyve-Sac3 (PAS) regulatory complex to trigger a unique loop of PtdIns3P-PtdIns(3,5)P2 synthesis and turnover. ...In these cells, knockdown of ArPIKfyve had only …
The phosphoinositide 5-kinase PIKfyve and 5-phosphatase Sac3 are scaffolded by ArPIKfyve in the PIKfyve-ArPIKfyve-Sac3 (PAS) regulatory comp …
PtdIns5P: news and views of its appearance, disappearance and deeds.
Shisheva A. Shisheva A. Arch Biochem Biophys. 2013 Oct 15;538(2):171-80. doi: 10.1016/j.abb.2013.07.023. Epub 2013 Aug 2. Arch Biochem Biophys. 2013. PMID: 23916588 Free PMC article. Review.
Accumulated evidence indicates that PtdIns5P, one of the seven phosphoinositides, found now to be constitutively present in yeast, plants and metazoa, serves as a signaling molecule to modulate pleiotropic cellular functions in both the nucleus and the cytoplasm. ...
Accumulated evidence indicates that PtdIns5P, one of the seven phosphoinositides, found now to be constitutively present in yeast, plants an …
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