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Curcumin down regulates smokeless tobacco-induced NF-kappaB activation and COX-2 expression in human oral premalignant and cancer cells.
Sharma C, Kaur J, Shishodia S, Aggarwal BB, Ralhan R. Sharma C, et al. Among authors: shishodia s. Toxicology. 2006 Nov 10;228(1):1-15. doi: 10.1016/j.tox.2006.07.027. Epub 2006 Aug 12. Toxicology. 2006. PMID: 16996673
Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.
Nair AS, Shishodia S, Ahn KS, Kunnumakkara AB, Sethi G, Aggarwal BB. Nair AS, et al. Among authors: shishodia s. J Immunol. 2006 Oct 15;177(8):5612-22. doi: 10.4049/jimmunol.177.8.5612. J Immunol. 2006. PMID: 17015749
Expression of NF-kappaB parallels COX-2 expression in oral precancer and cancer: association with smokeless tobacco.
Sawhney M, Rohatgi N, Kaur J, Shishodia S, Sethi G, Gupta SD, Deo SV, Shukla NK, Aggarwal BB, Ralhan R. Sawhney M, et al. Among authors: shishodia s. Int J Cancer. 2007 Jun 15;120(12):2545-56. doi: 10.1002/ijc.22657. Int J Cancer. 2007. PMID: 17354234
Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products.
Sandur SK, Ahn KS, Ichikawa H, Sethi G, Shishodia S, Newman RA, Aggarwal BB. Sandur SK, et al. Among authors: shishodia s. Nutr Cancer. 2007;57(1):78-87. doi: 10.1080/01635580701268295. Nutr Cancer. 2007. PMID: 17516865
Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.
Shishodia S, Sethi G, Ahn KS, Aggarwal BB. Shishodia S, et al. Biochem Pharmacol. 2007 Jun 30;74(1):118-30. doi: 10.1016/j.bcp.2007.03.026. Epub 2007 Mar 30. Biochem Pharmacol. 2007. PMID: 17475222 Free PMC article.
Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.
Aggarwal BB, Banerjee S, Bharadwaj U, Sung B, Shishodia S, Sethi G. Aggarwal BB, et al. Among authors: shishodia s. Biochem Pharmacol. 2007 Apr 1;73(7):1024-32. doi: 10.1016/j.bcp.2006.12.010. Epub 2006 Dec 15. Biochem Pharmacol. 2007. PMID: 17240359 Retracted.
PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway.
Koul D, Shen R, Shishodia S, Takada Y, Bhat KP, Reddy SA, Aggarwal BB, Yung WK. Koul D, et al. Among authors: shishodia s. Mol Cell Biochem. 2007 Jun;300(1-2):77-87. doi: 10.1007/s11010-006-9371-8. Epub 2007 Jan 18. Mol Cell Biochem. 2007. PMID: 17235455
Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.
Bhardwaj A, Sethi G, Vadhan-Raj S, Bueso-Ramos C, Takada Y, Gaur U, Nair AS, Shishodia S, Aggarwal BB. Bhardwaj A, et al. Among authors: shishodia s. Blood. 2007 Mar 15;109(6):2293-302. doi: 10.1182/blood-2006-02-003988. Epub 2006 Dec 12. Blood. 2007. PMID: 17164350
Nuclear factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and preneoplastic lesions.
Tang X, Liu D, Shishodia S, Ozburn N, Behrens C, Lee JJ, Hong WK, Aggarwal BB, Wistuba II. Tang X, et al. Among authors: shishodia s. Cancer. 2006 Dec 1;107(11):2637-46. doi: 10.1002/cncr.22315. Cancer. 2006. PMID: 17078054
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