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Sequence-Selective Covalent CaaX-Box Receptors Prevent Farnesylation of Oncogenic Ras Proteins and Impact MAPK/PI3 K Signaling.
ChemMedChem. 2021 Aug 19;16(16):2504-2514. doi: 10.1002/cmdc.202100167. Epub 2021 May 19.
ChemMedChem. 2021.
PMID: 33899342
Free PMC article.
Synthesis, Biological Evaluation, and Binding Mode of a New Class of Oncogenic K-Ras4b Inhibitors.
Jeuken S, Shkura O, Röger M, Brickau V, Choidas A, Degenhart C, Gülden D, Klebl B, Koch U, Stoll R, Scherkenbeck J.
Jeuken S, et al. Among authors: shkura o.
ChemMedChem. 2022 Nov 18;17(22):e202200392. doi: 10.1002/cmdc.202200392. Epub 2022 Sep 23.
ChemMedChem. 2022.
PMID: 35979853
Free PMC article.
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Allosteric Activation of GDP-Bound Ras Isoforms by Bisphenol Derivative Plasticisers.
Schöpel M, Shkura O, Seidel J, Kock K, Zhong X, Löffek S, Helfrich I, Bachmann HS, Scherkenbeck J, Herrmann C, Stoll R.
Schöpel M, et al. Among authors: shkura o.
Int J Mol Sci. 2018 Apr 10;19(4):1133. doi: 10.3390/ijms19041133.
Int J Mol Sci. 2018.
PMID: 29642594
Free PMC article.
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Targeting the "undruggable" RAS - new strategies - new hope?
Mörchen B, Shkura O, Stoll R, Helfrich I.
Mörchen B, et al. Among authors: shkura o.
Cancer Drug Resist. 2019 Sep 19;2(3):813-826. doi: 10.20517/cdr.2019.21. eCollection 2019.
Cancer Drug Resist. 2019.
PMID: 35582595
Free PMC article.
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