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Page 1
Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils.
Tullo S, Park J, Gallino D, Park M, Mar K, Novikov V, Sandoval Contreras R, Patel R, Del Cid-Pellitero E, Fon EA, Luo W, Shlaifer I, Durcan TM, Prado MAM, Prado VF, Devenyi GA, Chakravarty MM. Tullo S, et al. Among authors: shlaifer i. Commun Biol. 2025 Feb 22;8(1):288. doi: 10.1038/s42003-025-07680-1. Commun Biol. 2025. PMID: 39987244 Free PMC article.
A guide to selecting high-performing antibodies for VAPB (UniProt ID: O95292) for use in western blot, immunoprecipitation, and immunofluorescence.
González Bolívar S, Ayoubi R, Alende C, Fothouhi M, Shlaifer I, McPherson PS, Laflamme C; NeuroSGC/YCharOS/EDDU collaborative group; ABIF consortium. González Bolívar S, et al. Among authors: shlaifer i. F1000Res. 2024 Dec 24;13:1559. doi: 10.12688/f1000research.160226.1. eCollection 2024. F1000Res. 2024. PMID: 39916983 Free PMC article.
Modeling Parkinson's disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines.
Bayati A, Ayoubi R, Aguila A, Zorca CE, Deyab G, Han C, Recinto SJ, Nguyen-Renou E, Rocha C, Maussion G, Luo W, Shlaifer I, Banks E, McDowell I, Del Cid Pellitero E, Ding XE, Sharif B, Séguéla P, Yaqubi M, Chen CX, You Z, Abdian N, McBride HM, Fon EA, Stratton JA, Durcan TM, Nahirney PC, McPherson PS. Bayati A, et al. Among authors: shlaifer i. Nat Neurosci. 2024 Dec;27(12):2401-2416. doi: 10.1038/s41593-024-01775-4. Epub 2024 Oct 8. Nat Neurosci. 2024. PMID: 39379564
An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders.
Dorion MF, Casas D, Shlaifer I, Yaqubi M, Fleming P, Karpilovsky N, Chen CX, Nicouleau M, Piscopo VEC, MacDougall EJ, Alluli A, Goldsmith TM, Schneider A, Dorion S, Aprahamian N, MacDonald A, Thomas RA, Dudley RWR, Hall JA, Fon EA, Antel JP, Stratton JA, Durcan TM, La Piana R, Healy LM. Dorion MF, et al. Among authors: shlaifer i. Mol Neurodegener. 2024 Apr 5;19(1):31. doi: 10.1186/s13024-024-00723-x. Mol Neurodegener. 2024. PMID: 38576039 Free PMC article.
USP19 deubiquitinase inactivation regulates α-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice.
Schorova L, Bedard N, Khayachi A, Ho HH, Bolivar-Pedroso J, Huynh J, Piccirelli M, Wang Y, Plourde M, Luo W, Del Cid-Pellitero E, Shlaifer I, Castellanos-Montiel MJ, Yu Z, Valenzuela DVC, Lacalle-Aurioles M, Kriz A, Ye Y, Durcan TM, Wing SS. Schorova L, et al. Among authors: shlaifer i. NPJ Parkinsons Dis. 2023 Nov 28;9(1):157. doi: 10.1038/s41531-023-00601-1. NPJ Parkinsons Dis. 2023. PMID: 38017009 Free PMC article.
Neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy prior to onset of motor symptoms.
Tullo S, Miranda AS, Del Cid-Pellitero E, Lim MP, Gallino D, Attaran A, Patel R, Novikov V, Park M, Beraldo FH, Luo W, Shlaifer I, Durcan TM, Bussey TJ, Saksida LM, Fon EA, Prado VF, Prado MAM, Chakravarty MM. Tullo S, et al. Among authors: shlaifer i. J Neurochem. 2024 Aug;168(8):1546-1564. doi: 10.1111/jnc.15967. Epub 2023 Oct 7. J Neurochem. 2024. PMID: 37804203
MerTK is a mediator of alpha-synuclein fibril uptake by human microglia.
Dorion MF, Yaqubi M, Senkevich K, Kieran NW, MacDonald A, Chen CXQ, Luo W, Wallis A, Shlaifer I, Hall JA, Dudley RWR, Glass IA; Birth Defects Research Laboratory; Stratton JA, Fon EA, Bartels T, Antel JP, Gan-Or Z, Durcan TM, Healy LM. Dorion MF, et al. Among authors: shlaifer i. Brain. 2024 Feb 1;147(2):427-443. doi: 10.1093/brain/awad298. Brain. 2024. PMID: 37671615 Free PMC article.
The identification of high-performing antibodies for Charged multivesicular body protein 2b for use in Western Blot, immunoprecipitation and immunofluorescence.
Alshafie W, Fotouhi M, Ayoubi R, Shlaifer I, Southern K, McPherson PS, Laflamme C; NeuroSGC/YCharOS/EDDU collaborative group. Alshafie W, et al. Among authors: shlaifer i. F1000Res. 2023 Jul 25;12:884. doi: 10.12688/f1000research.139755.1. eCollection 2023. F1000Res. 2023. PMID: 37635943 Free PMC article.
20 results