Shoichet BK - Search Results

1

Stability for function trade-offs in the enolase superfamily "catalytic module".

Nagatani RA, Gonzalez A, Shoichet BK, Brinen LS, Babbitt PC. Nagatani RA, et al. Among authors: shoichet bk. Biochemistry. 2007 Jun 12;46(23):6688-95. doi: 10.1021/bi700507d. Epub 2007 May 16. Biochemistry. 2007. PMID: 17503785

2

A relationship between protein stability and protein function.

Shoichet BK, Baase WA, Kuroki R, Matthews BW. Shoichet BK, et al. Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):452-6. doi: 10.1073/pnas.92.2.452. Proc Natl Acad Sci U S A. 1995. PMID: 7831309 Free PMC article.

3

Partial restoration of activity to Lactobacillus casei thymidylate synthase following inactivation by domain deletion.

Schellenberger U, Balaram P, Francis VS, Shoichet BK, Santi DV. Schellenberger U, et al. Among authors: shoichet bk. Biochemistry. 1994 May 10;33(18):5623-9. doi: 10.1021/bi00184a034. Biochemistry. 1994. PMID: 8180187

4

Structure-based discovery of inhibitors of thymidylate synthase.

Shoichet BK, Stroud RM, Santi DV, Kuntz ID, Perry KM. Shoichet BK, et al. Science. 1993 Mar 5;259(5100):1445-50. doi: 10.1126/science.8451640. Science. 1993. PMID: 8451640

5

Three-dimensional structure of AmpC beta-lactamase from Escherichia coli bound to a transition-state analogue: possible implications for the oxyanion hypothesis and for inhibitor design.

Usher KC, Blaszczak LC, Weston GS, Shoichet BK, Remington SJ. Usher KC, et al. Among authors: shoichet bk. Biochemistry. 1998 Nov 17;37(46):16082-92. doi: 10.1021/bi981210f. Biochemistry. 1998. PMID: 9819201

6

Structure-based design of inhibitors specific for bacterial thymidylate synthase.

Stout TJ, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Santi DV, Kuntz ID, Stroud RM, Shoichet BK, Costi MP. Stout TJ, et al. Among authors: shoichet bk. Biochemistry. 1999 Feb 2;38(5):1607-17. doi: 10.1021/bi9815896. Biochemistry. 1999. PMID: 9931028

7

Comparing the thermodynamic stabilities of a related thermophilic and mesophilic enzyme.

Beadle BM, Baase WA, Wilson DB, Gilkes NR, Shoichet BK. Beadle BM, et al. Among authors: shoichet bk. Biochemistry. 1999 Feb 23;38(8):2570-6. doi: 10.1021/bi9824902. Biochemistry. 1999. PMID: 10029552

8

Inhibition of AmpC beta-lactamase through a destabilizing interaction in the active site.

Trehan I, Beadle BM, Shoichet BK. Trehan I, et al. Among authors: shoichet bk. Biochemistry. 2001 Jul 10;40(27):7992-9. doi: 10.1021/bi010641m. Biochemistry. 2001. PMID: 11434768

9

Structures of ceftazidime and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design.

Powers RA, Caselli E, Focia PJ, Prati F, Shoichet BK. Powers RA, et al. Among authors: shoichet bk. Biochemistry. 2001 Aug 7;40(31):9207-14. doi: 10.1021/bi0109358. Biochemistry. 2001. PMID: 11478888

10

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs.

Wang X, Minasov G, Shoichet BK. Wang X, et al. Among authors: shoichet bk. J Mol Biol. 2002 Jun 28;320(1):85-95. doi: 10.1016/S0022-2836(02)00400-X. J Mol Biol. 2002. PMID: 12079336

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