Shoichet BK - Search Results

1

Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors.

Coan KE, Shoichet BK. Coan KE, et al. Among authors: shoichet bk. J Am Chem Soc. 2008 Jul 23;130(29):9606-12. doi: 10.1021/ja802977h. Epub 2008 Jun 28. J Am Chem Soc. 2008. PMID: 18588298 Free PMC article.

2

Nanomolar inhibitors of AmpC beta-lactamase.

Morandi F, Caselli E, Morandi S, Focia PJ, Blázquez J, Shoichet BK, Prati F. Morandi F, et al. Among authors: shoichet bk. J Am Chem Soc. 2003 Jan 22;125(3):685-95. doi: 10.1021/ja0288338. J Am Chem Soc. 2003. PMID: 12526668

3

Identification and prediction of promiscuous aggregating inhibitors among known drugs.

Seidler J, McGovern SL, Doman TN, Shoichet BK. Seidler J, et al. Among authors: shoichet bk. J Med Chem. 2003 Oct 9;46(21):4477-86. doi: 10.1021/jm030191r. J Med Chem. 2003. PMID: 14521410

4

Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture.

Tondi D, Morandi F, Bonnet R, Costi MP, Shoichet BK. Tondi D, et al. Among authors: shoichet bk. J Am Chem Soc. 2005 Apr 6;127(13):4632-9. doi: 10.1021/ja042984o. J Am Chem Soc. 2005. PMID: 15796528 Free PMC article.

5

Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases.

Chen Y, Shoichet B, Bonnet R. Chen Y, et al. J Am Chem Soc. 2005 Apr 20;127(15):5423-34. doi: 10.1021/ja042850a. J Am Chem Soc. 2005. PMID: 15826180 Free PMC article.

6

High-throughput assays for promiscuous inhibitors.

Feng BY, Shelat A, Doman TN, Guy RK, Shoichet BK. Feng BY, et al. Among authors: shoichet bk. Nat Chem Biol. 2005 Aug;1(3):146-8. doi: 10.1038/nchembio718. Epub 2005 Jul 3. Nat Chem Biol. 2005. PMID: 16408018

7

The deacylation mechanism of AmpC beta-lactamase at ultrahigh resolution.

Chen Y, Minasov G, Roth TA, Prati F, Shoichet BK. Chen Y, et al. Among authors: shoichet bk. J Am Chem Soc. 2006 Mar 8;128(9):2970-6. doi: 10.1021/ja056806m. J Am Chem Soc. 2006. PMID: 16506777 Free PMC article.

8

Synergy and antagonism of promiscuous inhibition in multiple-compound mixtures.

Feng BY, Shoichet BK. Feng BY, et al. Among authors: shoichet bk. J Med Chem. 2006 Apr 6;49(7):2151-4. doi: 10.1021/jm060029z. J Med Chem. 2006. PMID: 16570910 Free PMC article.

9

Screening in a spirit haunted world.

Shoichet BK. Shoichet BK. Drug Discov Today. 2006 Jul;11(13-14):607-15. doi: 10.1016/j.drudis.2006.05.014. Drug Discov Today. 2006. PMID: 16793529 Free PMC article. Review.

10

Predicting substrates by docking high-energy intermediates to enzyme structures.

Hermann JC, Ghanem E, Li Y, Raushel FM, Irwin JJ, Shoichet BK. Hermann JC, et al. Among authors: shoichet bk. J Am Chem Soc. 2006 Dec 13;128(49):15882-91. doi: 10.1021/ja065860f. J Am Chem Soc. 2006. PMID: 17147401

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