Shoichet BK - Search Results

1

Promiscuous aggregate-based inhibitors promote enzyme unfolding.

Coan KE, Maltby DA, Burlingame AL, Shoichet BK. Coan KE, et al. Among authors: shoichet bk. J Med Chem. 2009 Apr 9;52(7):2067-75. doi: 10.1021/jm801605r. J Med Chem. 2009. PMID: 19281222 Free PMC article.

2

Structure-based discovery of inhibitors of thymidylate synthase.

Shoichet BK, Stroud RM, Santi DV, Kuntz ID, Perry KM. Shoichet BK, et al. Science. 1993 Mar 5;259(5100):1445-50. doi: 10.1126/science.8451640. Science. 1993. PMID: 8451640

3

Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.

Weston GS, Blázquez J, Baquero F, Shoichet BK. Weston GS, et al. Among authors: shoichet bk. J Med Chem. 1998 Nov 5;41(23):4577-86. doi: 10.1021/jm980343w. J Med Chem. 1998. PMID: 9804697

4

Structure-based design of inhibitors specific for bacterial thymidylate synthase.

Stout TJ, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Santi DV, Kuntz ID, Stroud RM, Shoichet BK, Costi MP. Stout TJ, et al. Among authors: shoichet bk. Biochemistry. 1999 Feb 2;38(5):1607-17. doi: 10.1021/bi9815896. Biochemistry. 1999. PMID: 9931028

5

Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase.

Tondi D, Slomczynska U, Costi MP, Watterson DM, Ghelli S, Shoichet BK. Tondi D, et al. Among authors: shoichet bk. Chem Biol. 1999 May;6(5):319-31. doi: 10.1016/S1074-5521(99)80077-5. Chem Biol. 1999. PMID: 10322126

6

Functional analyses of AmpC beta-lactamase through differential stability.

Beadle BM, McGovern SL, Patera A, Shoichet BK. Beadle BM, et al. Among authors: shoichet bk. Protein Sci. 1999 Sep;8(9):1816-24. doi: 10.1110/ps.8.9.1816. Protein Sci. 1999. PMID: 10493583 Free PMC article.

7

Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases.

Caselli E, Powers RA, Blasczcak LC, Wu CY, Prati F, Shoichet BK. Caselli E, et al. Among authors: shoichet bk. Chem Biol. 2001 Jan;8(1):17-31. doi: 10.1016/s1074-5521(00)00052-1. Chem Biol. 2001. PMID: 11182316

8

Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase.

Tondi D, Powers RA, Caselli E, Negri MC, Blázquez J, Costi MP, Shoichet BK. Tondi D, et al. Among authors: shoichet bk. Chem Biol. 2001 Jun;8(6):593-611. doi: 10.1016/s1074-5521(01)00034-5. Chem Biol. 2001. PMID: 11410378

9

A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening.

McGovern SL, Caselli E, Grigorieff N, Shoichet BK. McGovern SL, et al. Among authors: shoichet bk. J Med Chem. 2002 Apr 11;45(8):1712-22. doi: 10.1021/jm010533y. J Med Chem. 2002. PMID: 11931626

10

Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B.

Doman TN, McGovern SL, Witherbee BJ, Kasten TP, Kurumbail R, Stallings WC, Connolly DT, Shoichet BK. Doman TN, et al. Among authors: shoichet bk. J Med Chem. 2002 May 23;45(11):2213-21. doi: 10.1021/jm010548w. J Med Chem. 2002. PMID: 12014959

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