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Grape seed extract targets mitochondrial electron transport chain complex III and induces oxidative and metabolic stress leading to cytoprotective autophagy and apoptotic death in human head and neck cancer cells.
Shrotriya S, Deep G, Lopert P, Patel M, Agarwal R, Agarwal C. Shrotriya S, et al. Mol Carcinog. 2015 Dec;54(12):1734-47. doi: 10.1002/mc.22246. Epub 2014 Dec 31. Mol Carcinog. 2015. PMID: 25557495 Free PMC article.
Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation.
Derry MM, Raina K, Balaiya V, Jain AK, Shrotriya S, Huber KM, Serkova NJ, Agarwal R, Agarwal C. Derry MM, et al. Among authors: Shrotriya S. Cancer Prev Res (Phila). 2013 Jul;6(7):625-33. doi: 10.1158/1940-6207.CAPR-13-0053. Epub 2013 May 2. Cancer Prev Res (Phila). 2013. PMID: 23639480 Free PMC article.
Poly[3-(3, 4-dihydroxyphenyl) glyceric acid] from Comfrey exerts anti-cancer efficacy against human prostate cancer via targeting androgen receptor, cell cycle arrest and apoptosis.
Shrotriya S, Gagan D, Ramasamy K, Raina K, Barbakadze V, Merlani M, Gogilashvili L, Amiranashvili L, Mulkijanyan K, Papadopoulos K, Agarwal C, Agarwal R. Shrotriya S, et al. Carcinogenesis. 2012 Aug;33(8):1572-80. doi: 10.1093/carcin/bgs202. Epub 2012 Jun 12. Carcinogenesis. 2012. PMID: 22693258 Free PMC article.
Mechanisms of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced DNA damage in skin epidermal cells and fibroblasts.
Inturi S, Tewari-Singh N, Gu M, Shrotriya S, Gomez J, Agarwal C, White CW, Agarwal R. Inturi S, et al. Among authors: Shrotriya S. Free Radic Biol Med. 2011 Dec 15;51(12):2272-80. doi: 10.1016/j.freeradbiomed.2011.08.020. Epub 2011 Aug 26. Free Radic Biol Med. 2011. PMID: 21920433 Free PMC article.
Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells.
Shrotriya S, Deep G, Gu M, Kaur M, Jain AK, Inturi S, Agarwal R, Agarwal C. Shrotriya S, et al. Carcinogenesis. 2012 Apr;33(4):848-58. doi: 10.1093/carcin/bgs019. Epub 2012 Jan 19. Carcinogenesis. 2012. PMID: 22266465 Free PMC article.
Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses.
Shrotriya S, Tyagi A, Deep G, Orlicky DJ, Wisell J, Wang XJ, Sclafani RA, Agarwal R, Agarwal C. Shrotriya S, et al. Mol Carcinog. 2015 Apr;54(4):291-300. doi: 10.1002/mc.22099. Epub 2013 Nov 14. Mol Carcinog. 2015. PMID: 24243690 Free PMC article.
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