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Fibrillin-containing microfibrils: structure and function in health and disease.
Kielty CM, Shuttleworth CA. Kielty CM, et al. Among authors: shuttleworth ca. Int J Biochem Cell Biol. 1995 Aug;27(8):747-60. doi: 10.1016/1357-2725(95)00028-n. Int J Biochem Cell Biol. 1995. PMID: 7584608 Review.
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
Ball SG, Shuttleworth CA, Kielty CM. Ball SG, et al. Among authors: shuttleworth ca. J Cell Biol. 2007 May 7;177(3):489-500. doi: 10.1083/jcb.200608093. Epub 2007 Apr 30. J Cell Biol. 2007. PMID: 17470632 Free PMC article.
Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation.
Bax DV, Mahalingam Y, Cain S, Mellody K, Freeman L, Younger K, Shuttleworth CA, Humphries MJ, Couchman JR, Kielty CM. Bax DV, et al. Among authors: shuttleworth ca. J Cell Sci. 2007 Apr 15;120(Pt 8):1383-92. doi: 10.1242/jcs.003954. Epub 2007 Mar 20. J Cell Sci. 2007. PMID: 17374638
Platelet-derived growth factor receptor-alpha is a key determinant of smooth muscle alpha-actin filaments in bone marrow-derived mesenchymal stem cells.
Ball SG, Shuttleworth CA, Kielty CM. Ball SG, et al. Among authors: shuttleworth ca. Int J Biochem Cell Biol. 2007;39(2):379-91. doi: 10.1016/j.biocel.2006.09.005. Epub 2006 Sep 24. Int J Biochem Cell Biol. 2007. PMID: 17070723
Heparan sulfate regulates fibrillin-1 N- and C-terminal interactions.
Cain SA, Baldwin AK, Mahalingam Y, Raynal B, Jowitt TA, Shuttleworth CA, Couchman JR, Kielty CM. Cain SA, et al. Among authors: shuttleworth ca. J Biol Chem. 2008 Oct 3;283(40):27017-27. doi: 10.1074/jbc.M803373200. Epub 2008 Jul 31. J Biol Chem. 2008. PMID: 18669635 Free article.
Molecular basis of elastic fiber formation. Critical interactions and a tropoelastin-fibrillin-1 cross-link.
Rock MJ, Cain SA, Freeman LJ, Morgan A, Mellody K, Marson A, Shuttleworth CA, Weiss AS, Kielty CM. Rock MJ, et al. Among authors: shuttleworth ca. J Biol Chem. 2004 May 28;279(22):23748-58. doi: 10.1074/jbc.M400212200. Epub 2004 Mar 23. J Biol Chem. 2004. PMID: 15039439
Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta.
Massam-Wu T, Chiu M, Choudhury R, Chaudhry SS, Baldwin AK, McGovern A, Baldock C, Shuttleworth CA, Kielty CM. Massam-Wu T, et al. Among authors: shuttleworth ca. J Cell Sci. 2010 Sep 1;123(Pt 17):3006-18. doi: 10.1242/jcs.073437. Epub 2010 Aug 10. J Cell Sci. 2010. PMID: 20699357 Free PMC article.
Fibrillin-1 microfibril deposition is dependent on fibronectin assembly.
Kinsey R, Williamson MR, Chaudhry S, Mellody KT, McGovern A, Takahashi S, Shuttleworth CA, Kielty CM. Kinsey R, et al. Among authors: shuttleworth ca. J Cell Sci. 2008 Aug 15;121(Pt 16):2696-704. doi: 10.1242/jcs.029819. Epub 2008 Jul 24. J Cell Sci. 2008. PMID: 18653538 Free article.
Fibrillin-1 regulates the bioavailability of TGFbeta1.
Chaudhry SS, Cain SA, Morgan A, Dallas SL, Shuttleworth CA, Kielty CM. Chaudhry SS, et al. Among authors: shuttleworth ca. J Cell Biol. 2007 Jan 29;176(3):355-67. doi: 10.1083/jcb.200608167. Epub 2007 Jan 22. J Cell Biol. 2007. PMID: 17242066 Free PMC article.
Marfan syndrome-causing mutations in fibrillin-1 result in gross morphological alterations and highlight the structural importance of the second hybrid domain.
Mellody KT, Freeman LJ, Baldock C, Jowitt TA, Siegler V, Raynal BD, Cain SA, Wess TJ, Shuttleworth CA, Kielty CM. Mellody KT, et al. Among authors: shuttleworth ca. J Biol Chem. 2006 Oct 20;281(42):31854-62. doi: 10.1074/jbc.M602743200. Epub 2006 Aug 10. J Biol Chem. 2006. PMID: 16905551
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